Effects of Transcranial Direct Current Stimulation (tDCS) on GABA Concentration and Brain Functional Connectivity in Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- GABA concentration assessed by magnetic resonance spectroscopy (MRS) after anodal tDCS adjusted for baseline levels
研究概览
简要总结
The aim of this study is to investigate whether anodal tDCS over the left M1 leads to a decrease of GABA concentration and alterations of functional brain connectivity in older people, compared to sham tDCS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 66 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •unobtrusive neuropsychological screening
- •age: older adults of retirement age: ≥66 years
排除标准
- •Mild cognitive impairment (MCI) or other neurological diseases.
- •History of severe alcoholism or use of drugs.
- •Severe psychiatric disorders such as depression, psychosis (if not in remission) and severe untreated medical problems.
- •Contraindication for MRI (claustrophobia, metallic implants, ferromagnetic metals in the body, disorders of thermoregulation, pregnant women).
研究组 & 干预措施
Anodal tDCS
Anodal stimulation during resting state fMRI
干预措施: tDCS (Device)
Cathodal tDCS
Cathodal stimulation during resting state fMRI
干预措施: tDCS (Device)
Sham tDCS
Sham stimulation during resting state fMRI
干预措施: sham-tDCS (Device)
结局指标
主要结局
GABA concentration assessed by magnetic resonance spectroscopy (MRS) after anodal tDCS adjusted for baseline levels
时间窗: assessed immediately before and after a 15-min stimulation time
Investigation whether anodal tDCS leads to a significant reduction of M1-GABA concentration in older adults compared to sham stimulation.
次要结局
- Genotyping of learning related polymorphisms(assessed during baseline screening)
- Resting-state functional connectivity changes(assessed during a 15-min stimulation time)
- GABA concentration assessed by MRS before and after cathodal tDCS adjusted for baseline levels(assessed immediately before and after a 15-min stimulation time)
研究者
Agnes Flöel
Prof.Dr.
Charite University, Berlin, Germany