Predictive Factor Study of the Occurrence of Endometrial Cancer in Patients With Lynch Syndrome

Completed

• Conditions: Lynch Syndrome

• Registration Number: NCT04452266
• Lead Sponsor: University Hospital, Lille

Brief Summary

Lynch Syndrome increases Endometrial Cancer Occurrence in women due to failure in MisMatch Repair System. Lifetime Cumulative risk of developing endometrial Cancer is approximatively 40% in women with Lynch Syndrome.

Endometrial cancer is the third women cancer in France. Many risk factors are known in general population. Lots of factors are related to over exposure to estrogen.

Data about influence of general risk factors in Women with Lynch Syndrome are poor. Recently, a cohort study appears to have shown a significant decrease in the risk of endometrial cancer with multiparity, the use of hormonal contraception and late menopause in Lynch women. The impact of weight and certain metabolic parameters on the occurrence of endometrial cancers remains poorly known to this day.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-06-25
• Study First Submitted QC: 2020-06-29
• Study First Posted: 2020-06-30
• Study Start: 2020-08-14
• Primary Completion: 2020-10-20
• Study Completion: 2020-10-20
• Status Verified: 2021-03
• Last Update Submitted: 2021-03-08
• Last Update Posted: 2021-03-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 150

Inclusion Criteria

• Lynch Syndrome Diagnosis at University Hospital
• Alive at study time
• Age over 30 at endometrial cancer or Lynch Syndrome Diagnosis

Case group :

• No cancer before endometrial cancer diagnosis

Control group :

• No endometrial cancer developped
• Free cancer women at Lynch Syndrome diagnosis

Exclusion Criteria

• Refusing to participate
• Poor understanding of the French language
• Other cancer diagnosed before endometrial cancer
• Hysterectomy before lynch diagnosis for free cancer women

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation between endometrial cancer and predictif factors	Baseline	Endometrial cancer (yes/no) and explicative variable: Diabetes before endometrial cancer or Lynch syndrome diagnosis; Smoking ; Maximal Weight ; Age at menarche; Parity ; Age at first birth ; Contraceptive use.

Secondary Outcome Measures

Name	Time	Method
Correlation between endometrial cancer and predictif factors in post menopausal woman	Baseline	Endometrial cancer (yes/no) and explicative variable: Menopause age; Hormonal menopause treatment

Trial Locations

Locations (1)

Hôpital Jeanne de Flandres; 🇫🇷 Lille, France