Work Activity Augmented by Cognitive Rehabilitation: Continuation and Follow-up
Trial Snapshot
- Phase
- Phase 2
- Status
- Completed
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- Neuropsychological test performance
Study Overview
Brief Summary
This research investigates the benefits of productive activity and cognitive rehabilitation for patients with schizophrenia. Key questions are:
- does cognitive rehabilitation plus work activity produce better outcomes than work activity alone?
- Is cognitive rehabilitation more helpful for individuals with moderate or greater cognitive impairment than for individuals without such impairment?
- Does cognitive rehabilitation reduce the dropout rate and increase participation in work activity for cognitively impaired subjects?
- What features of cognitive rehabilitation are most important for clinical and rehabilitation outcomes?
Detailed Description
This is a randomized, matching study in which subjects are stratified by degree of cognitive impairment, then randomly assigned to one of two conditions: Work Services Only vs. Work Services plus cognitive rehabilitation. Longitudinal analysis of work activity, work performance, symptoms, quality of life, cognitive function and service utilization are made.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •diagnosis of schizophrenia or schizoaffective disorder
Exclusion Criteria
- •change in psychiatric medications or housing within 30 days of study intake
- •episode of drug abuse within 30 days of study intake
- •GAF score 30 or less
- •known neurological disease or developmental disability
Arms & Interventions
1
work therapy
Intervention: work therapy (Procedure)
1
work therapy
Intervention: work therapy (Behavioral)
2
work therapy plus cognitive remediation
Intervention: cognitive rehabilitation (Behavioral)
Outcomes
Primary Outcomes
Neuropsychological test performance
Time Frame: data collection completed
Secondary Outcomes
- Quality of life(data collection completed)
- Psychiatric symptoms(data collection completed)
- Hours of productive activity(data collection completed)
- Hours worked(data collection completed)