Epidemiological, Clinical, Microbiological and Outcome Description of Patients With Klebsiella sp Meningitis

Completed

• Conditions: Meningitis

• Registration Number: NCT03967210
• Lead Sponsor: Fondation Hôpital Saint-Joseph

Brief Summary

Klebsiella pneumoniae is implicated in the occurrence of severe pneumonia. Most Klebsiella pneumoniae infections are associated with care and occur in patients with compromised immune defenses. More recently, cases of hepatic abscess and acute community meningitis related to strains of Klebsiella pneumoniae have been reported. The mortality of these infections is important, most often due to a delayed diagnosis. The poor prognostic factors reported in the literature for very low numbers are: advanced age, coma, septic shock, glyceryachia \<10mg / dL and proteinuria\> 750 mg / dL. In addition, no study has specifically focused on the factors of occurrence and factors associated with Klebsiella sp. Indeed, meningitis related to Klebsiella pneumoniae seems to be a rare but probably underestimated event whose risk factors, clinical presentation, microbiological are little known and the treatment modalities of this severe infection are not codified.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-05-24
• Study First Submitted QC: 2019-05-29
• Study First Posted: 2019-05-30
• Study Start: 2019-07-05
• Primary Completion: 2019-12-31
• Study Completion: 2020-01-13
• Status Verified: 2021-08
• Last Update Submitted: 2021-08-20
• Last Update Posted: 2021-08-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 132

Inclusion Criteria

• Man or Woman whose age ≥ 18 years
• Patient with meningitis Klebsiella sp., hospitalized in one of the hospitals of the Clinical Microbiology Group
• Francophone patient

Exclusion Criteria

• Patient under tutorship or curatorship
• Patient deprived of liberty
• Patient under safeguard of justice
• Patient opposing his participation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Characterize meningitis with Klebsiella pneumoniae	Day 1	This corresponds to characterize Klebsiella pneumoniae meningitis, portal entry, secondary infection, associated antibiotic and associated therapies and the clinical course of patients.

Trial Locations

Locations (18)

CHU Tours; 🇫🇷 Tours, France

Hôpital Lariboisière; 🇫🇷 Paris, France

Hôpital Cochin; 🇫🇷 Paris, France

CHU Reims; 🇫🇷 Reims, France

CHU Lyon; 🇫🇷 Lyon, France

CHU Poitiers; 🇫🇷 Poitiers, France

CHU Rennes; 🇫🇷 Rennes, France

Hôpital Necker Enfants Malades; 🇫🇷 Paris, France

Hôpital Sainte Anne; 🇫🇷 Paris, France

CHU Strasbourg; 🇫🇷 Strasbourg, France

CHU Kremlin Bicetre; 🇫🇷 Paris, France

CHU Nice; 🇫🇷 Nice, France

Groupe Hospitalier Paris Saint-Joseph; 🇫🇷 Paris, France

CHU Nantes; 🇫🇷 Nantes, France

Hôpital Foch; 🇫🇷 Paris, France

CHU Brest; 🇫🇷 Brest, France

Hôpital henri Mondor; 🇫🇷 Créteil, France

CHU Caen; 🇫🇷 Caen, France