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临床试验/NCT03967210
NCT03967210已完成不适用

Epidemiological, Clinical, Microbiological and Outcome Description of Patients With Klebsiella sp Meningitis

Fondation Hôpital Saint-Joseph18 个研究点 分布在 1 个国家目标入组 132 人开始时间: 2019年7月5日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
132
试验地点
18
主要终点
Characterize meningitis with Klebsiella pneumoniae

研究概览

简要总结

Klebsiella pneumoniae is implicated in the occurrence of severe pneumonia. Most Klebsiella pneumoniae infections are associated with care and occur in patients with compromised immune defenses. More recently, cases of hepatic abscess and acute community meningitis related to strains of Klebsiella pneumoniae have been reported. The mortality of these infections is important, most often due to a delayed diagnosis. The poor prognostic factors reported in the literature for very low numbers are: advanced age, coma, septic shock, glyceryachia <10mg / dL and proteinuria> 750 mg / dL. In addition, no study has specifically focused on the factors of occurrence and factors associated with Klebsiella sp. Indeed, meningitis related to Klebsiella pneumoniae seems to be a rare but probably underestimated event whose risk factors, clinical presentation, microbiological are little known and the treatment modalities of this severe infection are not codified.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Man or Woman whose age ≥ 18 years
  • Patient with meningitis Klebsiella sp., hospitalized in one of the hospitals of the Clinical Microbiology Group
  • Francophone patient

排除标准

  • Patient under tutorship or curatorship
  • Patient deprived of liberty
  • Patient under safeguard of justice
  • Patient opposing his participation

结局指标

主要结局

Characterize meningitis with Klebsiella pneumoniae

时间窗: Day 1

This corresponds to characterize Klebsiella pneumoniae meningitis, portal entry, secondary infection, associated antibiotic and associated therapies and the clinical course of patients.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (18)

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