Listen in: Developing and Testing a Therapy Application for Patients With Speech Comprehension Deficits After Stroke.
- Conditions
- Aphasia
- Interventions
- Behavioral: Auditory comprehension therapy.
- Registration Number
- NCT02540889
- Lead Sponsor
- University College, London
- Brief Summary
The main aim is to develop and test the clinical efficacy of a novel, web based, rehabilitation application. Listen-In will provide an effective speech comprehension training tool that patients with aphasia can use to practice independently. This will free up therapists time to provide additional assessment, supervision and functional intervention in a highly cost effective manner.
- Detailed Description
The main aim is to develop and test the clinical efficacy of a novel, web based, rehabilitation application. Listen In will provide an effective speech comprehension training tool that patients can use to practice independently. This will free up SALT time to provide additional assessment, supervision and functional intervention in a highly cost effective manner.
Phase 1 (24 months. London, Newcastle, Cambridge): Development of Listen In, including diagnostic and therapeutic components, driven by patient user's feedback (alpha and beta testing). The intervention is detailed below and is based on current SALT practice. It will be adaptive, provide feedback and target auditory perception at many levels: the phonemic, lexical and sentence level processing of heard verbal stimuli, as well as auditory short term memory and nonverbal sound discrimination.
Phase 2 (12 months. London and Cambridge): A pilot, randomised, crossover, clinical trial of Listen-In in a group of aphasic patients in the chronic post-stroke period. A power calculation suggests that we will need 36 patents, 18 in each arm. The comparison will be standard SALT clinical care. The main outcome measure is a clinically relevant improvement on the comprehension of spoken language score of the Comprehensive Aphasia Test (Swinburn, 2004). Secondary outcomes include improvements in social activity and participation. The milestones for this phase will be: 50% recruitment into study and last patient, last visit.
Phase 3 (funded outside i4i grant) will be the rollout of the therapy application on the internet with a pragmatic trial of whether therapy gains can be made outside the confines of a clinical trial. The comparison will be on similar outcome measures as Phase 2 with a control test on sustained attention (internal control) that we predict will not improve with therapy.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 36
- any type of stroke but greater than 6 months post onset
- evidence of receptive aphasia
- English as their main language
- able to give informed consent
- age 18 years or above
- no diagnosis of degenerative brain disease.
- Stroke less than 6 months post onset
- No evidence of receptive aphasia
- English not their main language
- Unable to give informed consent
- Less than 18 years old
- diagnosis of degenerative brain disease.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description trial arm Auditory comprehension therapy. 100 hours of therapy.
- Primary Outcome Measures
Name Time Method Improvement in auditory comprehension on the comprehensive aphasia test. Measured over 36 weeks (0,12,24,36) weeks Investigation of improvement on a functionally relevant area of a widely used test of aphasia.
- Secondary Outcome Measures
Name Time Method Improvement in written language comprehension Measured over 36 weeks (0,12,24,36) weeks Investigation of improvement on a functionally relevant area of a widely used test of aphasia.
Improvement in functional communication Measured over 36 weeks (0,12,24,36) weeks Using patient reported outcomes to look at functional communication changes.
Performance on the Sustained attention to response task Measured over 36 weeks (0,12,24,36) weeks Investigation of improvement on sustained attention using the SART.
Environmental sounds test Measured over 36 weeks (0,12,24,36) weeks Investigation of improvement on the non verbal environmental sounds test.
Improvement in production of language Measured over 36 weeks (0,12,24,36) weeks Investigation of improvement on a functionally relevant area of a widely used test of aphasia.
Test of semantics Measured over 36 weeks (0,12,24,36) weeks Investigation of improvement in semantics knowledge.
Improvement on auditory descrimination Measured over 36 weeks (0,12,24,36) weeks Investigation of improvement on a test of auditory discrimination developed by Dr Holly Robson.
Trial Locations
- Locations (1)
UCLondon
🇬🇧London, United Kingdom