Maternal Pregnancy and Neonatal Outcome After Assisted Reproduction. Comparison of Vitrification vs. Spontaneous Conception
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 850
- 试验地点
- 1
- 主要终点
- Maternal pregancy outcome
研究概览
简要总结
Great scientific effort has been made to improve practical as well as economical procedures of modern assisted reproduction.
In the last years a shift from the well established method of slow-rate freezing to vitrification of 2PN zygotes and embryos could be observed. Like any other method of cryopreservation, the outcome of vitrification will be affected by several factors related to technique itself, its practical management and patient characteristics.
The investigators want to investigate the influence of vitrification on the outcome of of 2PN oocytes, pregnancy and infant health.
A Comparison between a cohort of spontaneous conceived children and children of vitrified and slow- cooled 2PN oocytes is planned.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •cryopreservation (vitrification and slow- rate freezing) between 1998 - 2010
- •Treatment in Lübeck University
- •Delivery in Lübeck University
- •Positive informed consent
排除标准
- •Negative informed consent
结局指标
主要结局
Maternal pregancy outcome
时间窗: 7 years
spontaneous or operative delivery, birth injuries, conjoined morbidity
embryo survival
时间窗: 7 years
embryo survival rate
次要结局
- infant health(7 years)
研究者
Daniel Alexander Beyer
Dr. D. A. Beyer
University of Luebeck