Maternal Pregnancy and Neonatal Outcome After Assisted Reproduction. Comparison of Vitrification vs. Spontaneous Conception
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pregnancy
- Sponsor
- University of Luebeck
- Enrollment
- 850
- Locations
- 1
- Primary Endpoint
- Maternal pregancy outcome
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Great scientific effort has been made to improve practical as well as economical procedures of modern assisted reproduction.
In the last years a shift from the well established method of slow-rate freezing to vitrification of 2PN zygotes and embryos could be observed. Like any other method of cryopreservation, the outcome of vitrification will be affected by several factors related to technique itself, its practical management and patient characteristics.
The investigators want to investigate the influence of vitrification on the outcome of of 2PN oocytes, pregnancy and infant health.
A Comparison between a cohort of spontaneous conceived children and children of vitrified and slow- cooled 2PN oocytes is planned.
Investigators
Daniel Alexander Beyer
Dr. D. A. Beyer
University of Luebeck
Eligibility Criteria
Inclusion Criteria
- •cryopreservation (vitrification and slow- rate freezing) between 1998 - 2010
- •Treatment in Lübeck University
- •Delivery in Lübeck University
- •Positive informed consent
Exclusion Criteria
- •Negative informed consent
Outcomes
Primary Outcomes
Maternal pregancy outcome
Time Frame: 7 years
spontaneous or operative delivery, birth injuries, conjoined morbidity
embryo survival
Time Frame: 7 years
embryo survival rate
Secondary Outcomes
- infant health(7 years)