Comparison of Single and Multiple-dose Methotrexate Therapy for Ectopic Pregnancy
Phase 4
Completed
- Conditions
- Pregnancy, Ectopic
- Interventions
- Drug: MultipeDrug: Single
- Registration Number
- NCT01662167
- Lead Sponsor
- Hormozgan University of Medical Sciences
- Brief Summary
The aim of this study was to compare single dose Methotrexate (MTX) to multiple dose MTX.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 87
Inclusion Criteria
- unruptured tubal EP
- gestational mass of less than or equal to 3.5 cm in ultrasonography report
Exclusion Criteria
- hemodynamic instability
- contraindications related to the use of MTX
- hepatic
- renal and active pulmonary diseases
- peptic ulcer
- immune deficiency status
- alcohol abuse
- blood dyscreasia
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Multiple dose mtx Multipe mtx Single Dose Single In the single dose regimen, 50 mg/m2 intramuscular methotrexate was given on day one and hCG level was measured on days four and seven. If the hCG level did not decrease by 15% between day four and seven, a second dose of methotrexate was injected on day seven, hCG level was measured weekly until a level of 15 mlU/ml or less was achieved
- Primary Outcome Measures
Name Time Method hCG level decrease 4 days after administration
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Shariaty Hospital
🇮🇷Bandar Abbas, Hormozgan, Iran, Islamic Republic of