Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus
试验速览
- 阶段
- 1 期
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- the effects of this Drug on OLP measured with VAS scale for pain and evaluation of intensity of lesions.
研究概览
简要总结
Lichen planus (LP) is a common chronic inflammatory mucocutaneous disease with an immunologic etiology ,which has number of different clinical forms. Alternative natural or herbal origine drugs with antioxidant and anti-inflammatory properties have been used individually or in combination with systemic corticosteroids in order to decrease adverse drug reactions.
This study was conducted to evaluate the effect of quercetin on treatment of erosive -atrophic lesions of oral lichen planus (OLP).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 12 Years 至 60 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •confirmation of clinical diagnosis of Atrophic and erosive lichen planus by histological examination
- •two weeks wash out periods after the last treatment
- •having the experience of atrophic and erosive lesion greater than 1 cm having the experience of pain and burning greater than 3.5 in VAS Score
排除标准
- •confirmation of dysplasia and malignancy in histologic examination
- •confirmation of lichenoid reaction in histologic examination
- •pregnancy and breast feeding
- •using fluorokinolon and cyclosporin which interact with quercetin
研究组 & 干预措施
quercetin
quercetin is one of flavonoids , and having therapeutical anti-inflammatory and antioxidant action
干预措施: Quercetin (Drug)
placebo
placebo capsul is produced with lactose for using in placebo/ control group.
干预措施: placebo (Drug)
结局指标
主要结局
the effects of this Drug on OLP measured with VAS scale for pain and evaluation of intensity of lesions.
时间窗: 2 months
In the present work the Analogical Visual Scale is used TO evaluate pain,and we also record the intensity of lesions weekly and any side effect of this Drug
次要结局
未报告次要终点