Comparison of Effects on Hemodynamics Between Ketamine and Etomidate During Rapid Sequence Intubation in Trauma Patients With High Shock Index
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Sponsor
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Systolic blood pressure difference compared with baseline after 10 minutes
Study Overview
Brief Summary
In trauma patients with high shock index, the investigators compare the effects on hemodynamics between ketamine and etomidate.
Detailed Description
In trauma patients, rapid sequence intubation is recommended. The drug of choice, however, has been debated. One cohort comparative study showed ketamine had benefit in hemodynamics compared to etomidate in trauma patients. One observational study showed in high shock index patients, ketamine showed maintain systolic blood pressure. And other retrospective showed less clinical hypotension was less in ketamine. However there is no randomized controlled study comparing ketamine and etomidate in trauma patients. The purpose of this study is comparing the effects of hemodynamics between ketamine and etomidate in high shock index trauma patients.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Other
- Masking
- None
Masking Description
open label
Eligibility Criteria
- Ages
- 19 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •age 19~70
- •Shock index ≥ 0.9
- •Patients who need intubation regarding to Ajou trauma center protocol
Exclusion Criteria
- •during CPR
- •CPR before hospital arrival
- •Severe head trauma
- •Steroid intake history
Arms & Interventions
Etomidate
The induction agent of rapid sequence intubation is etomidate. 0.2 mg/kg
Intervention: Etomidate Injection 0.2 mg/kg (Drug)
Ketamine
The induction agent of rapid sequence intubation is ketamine. 2 mg/kg
Intervention: Ketamine injection 2 mg/kg (Drug)
Outcomes
Primary Outcomes
Systolic blood pressure difference compared with baseline after 10 minutes
Time Frame: 13 minutes
Systolic blood pressure 10 minutes after induction agent injection - baseline systolic blood pressure mmHg Positive or zero value means good result. Negative value means poor result.
Secondary Outcomes
- Incidence of hypotension(25 minutes)
- Intubating condition(5 minutes)
- Incidence of hypertension(25 miinutes)
Investigators
In-kyong Yi
Clinical assistant professor
Ajou University School of Medicine