The effect of locally applied autologous platelet-rich fibrin sealant on woundhealing

Completed

• Conditions: Cholelithiasis; Digestive System

• Registration Number: ISRCTN34481461
• Lead Sponsor: Vivolution A/S (Denmark)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-10-06
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Consecutive patients undergoing elective laparoscopic cholecystectomy, over 18 years old who have given written and verbal informed consent.

Exclusion Criteria

1. Not Danish-speaking
2. Demential
3. Pregnant or lactating women
4. Fertile women not using contraception
5. Patients on aspirin (acetylsalicylic acid [ASA]) or anticoagulants less than 7 days before surgery
6. Patients suffering from anaemia or coagulation disorders
7. Patients suffering from incompensated heart or lung disease

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Collagen synthesis

Secondary Outcome Measures

Name	Time	Method
1. Woundstrength<br>2. Production of type I and III collagen mRNA<br>3. Histology<br>4. Growthfactors<br>5. Unwanted effects