Effect of Meal Number, Frequency, and Form on Satiety and Metabolism After Weight Loss Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 33
- 试验地点
- 2
- 主要终点
- Changes in gut peptides after gastric bypass, during either a liquid or solid meal, or single or multiple isocaloric meals.
研究概览
简要总结
Analyze the effect of meal pattern (meal number, frequency, and form) on satiety, gut peptides, insulin, and glucose levels in individuals before and 12-15 months after gastric bypass surgery (GBP).
详细描述
The main goal is to study the effect of meal number, size and texture on metabolism and incretin levels after GBP. Patients will be studied before GBP (T0) and 12-15 months after GBP (T1). At T0 and T1, patients will come for 2 study days for 8 hours: On one study day, a single meal will be served, on the second study day, three small isocaloric meals, with the order of the conditions randomly assigned. The total amount of calories and the overall nutrient composition will be equivalent between conditions. The meals will be either all solid or all liquid. Patients enrolled in the study will be randomly assigned to solid or liquid test meals.
Gastric emptying will be measured by the acetaminophen test.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Severely obese patients undergoing gastric bypass surgery (GBP)
排除标准
- 未提供
结局指标
主要结局
Changes in gut peptides after gastric bypass, during either a liquid or solid meal, or single or multiple isocaloric meals.
时间窗: 1 month before GBP Surgery, and 12-15 months post surgery
Changes in diet induced thermogenesis after gastric bypass, during either a liquid or solid meal, or single or multiple isocaloric meals.
时间窗: 1 month before GBP surgery, and 12-15 months post surgery
Changes in insulin levels after gastric bypass, during either a liquid or solid meal, or single or multiple isocaloric meals.
时间窗: 1 month before GBP surgery, 12-15 months post surgery
Changes in glucose levels after gastric bypass, during either a liquid or solid meal, or single or multiple isocaloric meals.
时间窗: 1 month before GBP , 12-15 months post GBP
Changes in satiety after gastric bypass, during either a liquid or solid meal, or single or multiple isocaloric meals.
时间窗: 1 month before GBP, 12-15 months post GBP
次要结局
未报告次要终点