Transcranial Magnetic Stimulation Effects on Nicotine Craving
- Conditions
- Nicotine Dependence
- Registration Number
- NCT01690130
- Lead Sponsor
- Medical University of South Carolina
- Brief Summary
The proposed study will measure the change of cortical excitability during nicotine craving and examine the effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on nicotine craving and cue-reactivity among adult regular smokers.
- Detailed Description
This pilot protocol proposes to test and further develop TMS for the purpose of studying brain function in nicotine users.
Specific Primary Aims include:
Aim # 1. To test change of cortical excitability during nicotine craving in cigarette smokers and explore the potential use of TMS in cigarette smokers.
Aim # 2. Given the role of the prefrontal cortex (and connected regions) in craving, we will examine whether modulating prefrontal activity through rTMS will impact measures of craving and the reinforcing effects of nicotine.
Design:
The study was a randomized, blind, sham-controlled crossover study in which participants will involve two study visits. Participants will have an initial assessment about tobacco use habits and craving patterns. Participant will look at images related to and not related to cigarette smoking.
Participants will receive two different types of brain stimulation with repetitive TMS (10 Hz): sham rTMS and active rTMS over prefrontal cortex. Craving assessments will be performed before and after each stimulus experiment.
Participants will be measured cortical excitability with TMS before and after each stimulus experiment.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 19
- Right handed males and females, between the ages of 18 and 50
- Daily smokers who smoke at least 10 cigarettes per day for at least past 1 year
- Mentally capable of reading, writing, giving consent, following instructions
- history of seizures
- taking medications that lower seizure threshold
- implanted metal devices (e.g., pacemakers, metal plates, wires)
- pregnant
- history of brain surgery or history of loss of consciousness >15 minutes
- any unstable major axis I psychiatric disorder in the past month (e.g. psychotic disorders)
- Current substance use disorders other than nicotine and caffeine use, in the past 30 days
- Any medication (e.g., propranolol) or unstable medical condition that may interfere with psychophysiological (e.g., heart rate) monitoring
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method the Change From Baseline in Cue Nicotine Craving Rating Score Before rMTS (baseline) and after rTMS experiment (on average 15 minutes) Seventy highly palatable scenic images, forty neutral control images) and forty cigarette smoking cue images were presented in four blocks. Immediately after viewing each block of cue images, participants completed a 10 question computerized visual analog scale (CVAS) designed to assess craving. Each question is followed by a CVAS (range 0 - 100) 0 means least amount of craving and 100 means the maximum amount of craving. After 15 minutes of real or sham rTMS, participants viewed the images again and rated their cravings. At each visit, participants were blind to the rTMS condition (real or sham) and the order was randomized.
- Secondary Outcome Measures
Name Time Method the Change From Baseline in Resting Motor Threshold 20 minutes before (baseline) and 20 minutes after rTMS experiment Resting Motor Threshold (RMT) on a scale from 0-100, with 100 being most power given to enact a motor response
Trial Locations
- Locations (1)
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States
Medical University of South Carolina🇺🇸Charleston, South Carolina, United States