NCT05268562进行中（未招募）4 期
Impact of Ketamine Versus Propofol for Anesthetic Induction on Acute Kidney Injury and Renal Biomarkers in Cardiac Surgery
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 进行中（未招募）
- 发起方
- Mayo Clinic
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Acute Kidney Injury
研究概览
简要总结
The purpose of this study is to investigate the affects of ketamine use for anesthesia at the beginning of heart surgery on kidneys compared to the use of propofol.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 70 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Presenting for cardiac surgery at the Mayo Clinic in Rochester, Minnesota.
- •Scheduled to undergo complex cardiac surgery with the use of cardiopulmonary bypass. Complex cardiac surgery will be defined as surgery involving more than one heart valve, redo-sternotomy procedures, or combined valvular and coronary artery bypass graft procedures (aortic repair not excluded if meets other criteria).
排除标准
- •Left or right ventricular assist device implantation or explantation.
- •Procedures not requiring cardiopulmonary bypass.
- •Active infection or sepsis requiring antimicrobial therapy and/or vasopressor therapy (treated endocarditis is not excluded).
- •Severe hepatic disease resulting in ascites.
- •Pre-operative significant renal dysfunction including a baseline creatinine equal to or greater than 2 mg/dL or requiring dialysis.
- •Immunosuppressive medication use (including current IV or oral steroids use, use of anti-rejection medications for transplant within 1 month, or chemotherapy within 6 months).
- •Immunodeficiency syndrome including HIV/AIDS, leukemia, and multiple myeloma
研究组 & 干预措施
Anesthesia induction with Propofol
Active Comparator
Subjects will receive Propofol to begin anesthesia for their cardiac surgery.
干预措施: Propofol (Drug)
Anesthesia induction with Ketamine
Active Comparator
Subjects will receive Ketamine to begin anesthesia for their cardiac surgery.
干预措施: Ketamine (Drug)
结局指标
主要结局
Acute Kidney Injury
时间窗: Immediately postop up to 10 days postoperatively
The incidence of acute kidney injury in patients following cardiac surgery
次要结局
- Vasopressor use(Immediately post induction up to 30 minute following induction)
研究者
Erica D. Wittwer, M.D., Ph.D.
Principal Investigator
Mayo Clinic
研究点 (1)
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