Neural Bases of Phantom Pain After Amputation

Not yet recruiting

• Conditions: Phantom Pain
• Interventions: Other: Questionnaires; Device: Brain and Spinal Cord functional Magnetic Resonance Imaging; Other: Proprioceptive training

• Registration Number: NCT05545358
• Lead Sponsor: Direction Centrale du Service de Santé des Armées

Brief Summary

The amputation of a limb results in chronic pain associated with the lost limb in the majority of patients, which persists over time. Despite a large number of studies conducted in an attempt to elucidate the neural basis of phantom pain, these are still not elucidated and current treatments often fail to relieve patients' pain.

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-09
• Study First Submitted: 2022-09-12
• Study First Submitted QC: 2022-09-16
• Last Update Submitted: 2022-09-16
• Study First Posted: 2022-09-19
• Last Update Posted: 2022-09-19
• Study Start: 2022-10
• Primary Completion: 2026-10
• Study Completion: 2026-10

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• Between 18 and 65 years old
• For the "amputees with phantom pain" group: patients who have been amputated for more than 2 years and have chronic phantom pain
• For the "amputees without phantom pain" group: patients who have been amputated for more than 2 years and do not have chronic phantom pain
• For the "healthy participants" group: healthy participants with no neurological history

Exclusion Criteria

• Clinically significant pathology (gastrointestinal, renal, hepatic, endocrine, cardiovascular or respiratory)
• Progressive psychiatric or neurological pathology
• On psychotropic medication
• Pregnant or nursing woman
• Inadequate level of French language

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Amputees with phantom pain	Brain and Spinal Cord functional Magnetic Resonance Imaging	Adult patients who have been amputated for more than 2 years and have chronic phantom pain
Amputees without phantom pain	Questionnaires	Adult patients who have been amputated for more than 2 years and do not have chronic phantom pain
Healthy participants	Brain and Spinal Cord functional Magnetic Resonance Imaging	Healthy adult participants with no neurological history
Amputees with phantom pain	Questionnaires	Adult patients who have been amputated for more than 2 years and have chronic phantom pain
Amputees with phantom pain	Proprioceptive training	Adult patients who have been amputated for more than 2 years and have chronic phantom pain
Amputees without phantom pain	Brain and Spinal Cord functional Magnetic Resonance Imaging	Adult patients who have been amputated for more than 2 years and do not have chronic phantom pain
Healthy participants	Proprioceptive training	Healthy adult participants with no neurological history

Primary Outcome Measures

Name	Time	Method
Change in brain activity, measured through fMRI, following proprioceptive training	Up to 3 months	Brain activity (BOLD hemodynamic response) will be measured via fMRI before and after proprioceptive training sessions.
Change in spinal cord activity, measured through spinal fMRI, following proprioceptive training	Up to 3 months	Spinal cord activity (BOLD hemodynamic response) will be measured via spinal fMRI before and after proprioceptive training sessions.