Experimental Study of the Neural Bases of Phantom Pain After Amputation and Their Modification by Proprioceptive Training: MRI Study of the Brain and Spinal Cord
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Phantom Pain
- Sponsor
- Direction Centrale du Service de Santé des Armées
- Enrollment
- 75
- Primary Endpoint
- Change in brain activity, measured through fMRI, following proprioceptive training
- Status
- Not yet recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
The amputation of a limb results in chronic pain associated with the lost limb in the majority of patients, which persists over time. Despite a large number of studies conducted in an attempt to elucidate the neural basis of phantom pain, these are still not elucidated and current treatments often fail to relieve patients' pain.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Between 18 and 65 years old
- •For the "amputees with phantom pain" group: patients who have been amputated for more than 2 years and have chronic phantom pain
- •For the "amputees without phantom pain" group: patients who have been amputated for more than 2 years and do not have chronic phantom pain
- •For the "healthy participants" group: healthy participants with no neurological history
Exclusion Criteria
- •Clinically significant pathology (gastrointestinal, renal, hepatic, endocrine, cardiovascular or respiratory)
- •Progressive psychiatric or neurological pathology
- •On psychotropic medication
- •Pregnant or nursing woman
- •Inadequate level of French language
Outcomes
Primary Outcomes
Change in brain activity, measured through fMRI, following proprioceptive training
Time Frame: Up to 3 months
Brain activity (BOLD hemodynamic response) will be measured via fMRI before and after proprioceptive training sessions.
Change in spinal cord activity, measured through spinal fMRI, following proprioceptive training
Time Frame: Up to 3 months
Spinal cord activity (BOLD hemodynamic response) will be measured via spinal fMRI before and after proprioceptive training sessions.