Effects of Liothyronine on Energy Expenditure and Cardiovascular Function

Phase 1

Completed

• Conditions: Healthy
• Interventions: Drug: Placebos; Drug: Liothyronine; Drug: Levothyroxine

• Registration Number: NCT03098433
• Lead Sponsor: Virginia Commonwealth University

Brief Summary

This study will assess the short term effects of a single dose of liothyronine on the cardiovascular system and energy expenditure

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-03-07
• Study First Submitted QC: 2017-03-27
• Study First Posted: 2017-03-31
• Study Start: 2017-10-20
• Primary Completion: 2019-06-24
• Study Completion: 2019-06-24
• Disposition First Submitted: 2020-07-07
• Results First Submitted: 2021-02-02
• Status Verified: 2021-03
• Results First Submitted QC: 2021-03-02
• Disposition First Submitted QC: 2021-03-02
• Last Update Submitted: 2021-03-02
• Results First Posted: 2021-03-26
• Disposition First Posted: 2021-03-26
• Last Update Posted: 2021-03-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

• BMI >20<30 kg/m2
• TSH >0.5<5.0 mcIU/mL
• Negative TPO antibodies

Exclusion Criteria

• Pregnancy
• Use of prescription drugs
• Diabetes mellitus
• Coronary artery disease
• Hypertension
• Anemia
• Renal insufficiency
• Liver disease or ALT >2.5 x the upper laboratory reference limit

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Placebo	Placebos	Each participant will receive a single dose of placebo
Liothyronine	Liothyronine	Each participant will receive a single dose of lithyronine
Levothyroxine	Levothyroxine	Each participant will receive a single dose of levothyroxine

Primary Outcome Measures

Name	Time	Method
Cardiac Output	five hours	Cardiac output measured by Echocaridogram, Difference in Stroke Volume Pre- and Post- Drug Administration

Secondary Outcome Measures

Name	Time	Method
Energy Expenditure	five hours	Energy expenditure measured by Whole-Room Indirect Calorimeter, Difference in energy Expenditure Pre- and Post- Drug Administration Kcal

Trial Locations

Locations (1)

Virginia Commonwealth University; 🇺🇸 Richmond, Virginia, United States