Efficacy of Intravenous Vitamin C Versus Placebo on Estimated Blood Loss in Total Abdominal Hysterectomy
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Intraoperative estimate blood loss
研究概览
简要总结
Intervention Group: Received two 1 gm doses of Vitamin C intravenously (IV). first Dose: At midnight on the day of surgery. Second Dose: Immediately after the surgical incision. Control Group: Received two doses of a normal saline intravenously (IV) at the exact same times.
The primary outcome was to compare intraoperative blood loss between patients who received intravenous Vitamin C and those who did not, following an abdominal hysterectomy under general anesthesia.
Intraoperative estimated blood loss (EBL) was meticulously quantified by weighing surgical gauze and measuring suction canister volumes.
The secondary outcomes were to evaluate the potential benefits of Vitamin C administration, including:
- Reduction in the decline of hematocrit levels after surgery.
- Reduction of the length of hospital stay
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Female patients who underwent total abdominal hysterectomy
- •No bleeding tendency.
- •No history of anticoagulant or thrombolytic drug use
- •No contraindications to vitamin C supplementation
排除标准
- •Inability to communicate in the Thai language.
- •Underwent total abdominal hysterectomy due to gynecologic malignancy.
- •Required emergency total abdominal hysterectomy.
- •History of vitamin C supplementation within 2 weeks prior to surgery.
- •History of smoking.
- •Previous abdominal surgery, such as bowel surgery, cesarean section
研究组 & 干预措施
Experimental: Vitamin C
Intervention Group: Received two 1 gm doses of Vitamin C intravenously (IV). first Dose: At midnight on the day of surgery. Second Dose: Immediately after the surgical incision. Control Group: Received two doses of a normal saline intravenously (IV) at the exact same times.
干预措施: Vitamin C (Ascorbic Acid) (Dietary Supplement)
Placebo
干预措施: Vitamin C (Ascorbic Acid) (Dietary Supplement)
结局指标
主要结局
Intraoperative estimate blood loss
时间窗: intraoperative
次要结局
未报告次要终点
研究者
Aektanat Tawornkitpanich
M.D.
Queen Savang Vadhana Memorial Hospital, Thailand