Long-term Evaluation of Fertility Preservation Options in Women in Cancer Remission or Haematological Pathology
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 102
- 试验地点
- 1
- 主要终点
- Occurrence of an identifiable reproductive outcome
研究概览
简要总结
Cancer treatments, despite their increasing effectiveness, carry a significant risk of gamete toxicity.
Women of reproductive age are commonly offered fertility preservation (FP) before starting their treatment.
However, few studies have analyzed the long-term reproductive outcomes of these interventions, nor how patients ultimately use or do not use the FP options once in remission.
This project aims to better understand the effectiveness, utilization, and psychological impacts of these strategies.
This work is part of an effort to understand and evaluate fertility preservation practices implemented for women of reproductive age undergoing cancer treatment at the Amiens-Picardie University Hospital (CHU).
Its objective is to document patient pathways, clinical decisions, techniques employed, and reproductive outcomes observed after remission, in order to identify potential areas for improvement in the support and follow-up of these patients, thereby enhancing the overall quality and coordination of care.
This work is conducted alongside the development of a fertility observatory at the Department of Medicine and Reproductive Biology, CHU Amiens-Picardie.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 47 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged between 18 and 47 years
- •Diagnosed with cancer or hematological disorders requiring potentially gonadotoxic treatment
- •Having undergone a medical fertility preservation consultation
- •Followed at Amiens Picardie University Hospital (CHU Amiens Picardie) in the department of Reproductive Medicine
- •Currently in remission
- •Having expressed non-opposition to participation in the study
排除标准
- •Absence of remission
- •Patients deprived of liberty by administrative or judicial decision, or placed under legal protection (guardianship or curators)
- •Decline to participate in the study
结局指标
主要结局
Occurrence of an identifiable reproductive outcome
时间窗: 1 year
Identifiable reproductive outcome are Spontaneous pregnancy, Use of preserved gametes or ovarian tissue (whether or not resulting in pregnancy), Use of donor oocytes, Discontinuation of the parenthood project
次要结局
- Type of fertility preservation method performed(1 year)
- Time interval (in months) between diagnosis and fertility preservation(1 year)
- Correlation between Age and occurance of an identifiable reproductive outcome(1 year)
- Time interval (in months) between fertility preservation and initiation of potentially gonadotoxic treatment(1 year)
- Number of type of cancer associated with identifiable reproductive outcome(1 year)
- Correlation between type of treatment and occurence of an identifiable reproductive outcome(1 year)
- Correlation between family status and occurence of an identifiable reproductive outcome(1 year)
- Time interval (in months) between completion of treatment and pregnancy attempt (spontaneous or medically assisted)(1 year)
- Actual utilization rate of preserved material(1 year)
- Success rate of reuse attempts(1 year)
- Proportion of patients who ultimately did not pursue parenthood(1 year)