NCT00159146终止不适用
A Short Term Double Blind Randomised Trial of Pindolol Augmentation in Venlafaxine Treated Patients With Major Depression
Hillerod Hospital, Denmark1 个研究点 分布在 1 个国家目标入组 31 人开始时间: 2002年8月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 31
- 试验地点
- 1
- 主要终点
- Hamilton Depression Rating Scale scores
研究概览
简要总结
This study investigates the hypothesis that pindolol can accelerate the response to antidepressants in patients with major depression treated with venlafaxine.
详细描述
Antidepressant therapy has a delayed onset of action of 4-6 weeks. Pindolol has in some studies shown an accelerating effect. In this study we investigate the effect of 20 mg of pindolol retarded formulation in combination with Venlafaxine compared to placebo Pindolol and Venlafaxine for a duration of 19 days.
Effect is measured by the Hamilton Depression rating Scale and the Preskorn Scale (self-rating).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Major depression
排除标准
- •Allergy towards pindolol, venlafaxine or other tablet constituents
- •Liver or kidney impairment
- •Diabetics
- •Age below 18 years
- •Severe cardiac disease
研究组 & 干预措施
A
Active Comparator
Venlafaxine and pindolol
干预措施: Pindolol and venlafaxin (Drug)
B
Placebo Comparator
Venlafaxin and placebo
干预措施: Pindolol and venlafaxin (Drug)
结局指标
主要结局
Hamilton Depression Rating Scale scores
时间窗: 1 week
次要结局
- Preskorn scores(one day)
研究者
研究点 (1)
Loading locations...
相似试验
终止
2 期
Riluzole Augmentation Pilot in Depression (RAPID) TrialMajor Depressive DisorderNCT01703039Brigham and Women's Hospital21
Unknown
2 期
A Study of Omega-3 as an Augmentor of Antidepressant Treatment for Major DepressionMajor DepressionNCT00289484The University of New South Wales52
终止
2 期
Rapid Antidepressant Effects of LeucineMajor Depressive DisorderNCT03079297University of Texas Southwestern Medical Center16
已完成
2 期
Adjunct Minocyline in Treatment-resistant DepressionMajor Depressive DisorderNCT02456948Charite University, Berlin, Germany168
终止
2 期
Riluzole to Treat Depression in Bipolar DisorderBipolar DisorderNCT00054704National Institute of Mental Health (NIMH)19