Glucocorticosteroid replacement therapy and fibrinolysis in hypopituitarism - Glucocorticoid replacement therapy and fibrinolysis
- Conditions
- Hypopituitarism
- Registration Number
- EUCTR2004-002056-34-GB
- Lead Sponsor
- Bradford Teaching Hospitals NHS Foundation Trust
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- Not specified
- Target Recruitment
- 15
Age >18 years
ACTH deficiency previously assessed by dynamic testing (eg. insulin stress test).
Currently taking replacement with hydrocotisone at optimal replacement dose.
prior written informed consent
Must be on stable dose of other pituitary replacement hormones where there is documented deficiency.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Subjects requiring systemic steroid therapy
Subjects taking high dose hormone replacement therapy or oral contraceptive tablets
Subjects who are currenlty pregnant or who have had a recent pregnancy or abortion
Subjects with known malignancy
Subjects with known coagulopathy
Subjects who are currently taking or who have recently taken anticoagulant therapy
Asian subjects and patients with diabetes millitus in whom abnormalities of the fibrinolytic system may exist.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: To compare and characterise the effect of different doses of glucocorticoid replacement therapy on fibrinolytic parameters.;Secondary Objective: N/A;Primary end point(s): Changes in fibrinolytic parameters eg. PAI-1, tPA
- Secondary Outcome Measures
Name Time Method