The Effect of Experimental Neck Pain in Healthy Participants - The Transition From Acute to Ongoing Pain
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Change in pressure pain threshold (PPT) measured with a handheld pressure algometer
研究概览
简要总结
This study investigates if/how an experimentally applied muscle pain/soreness, lasting for some days may affect brain activity, balance, movement patterns, muscle function and pain sensitivity in a healthy population
详细描述
All included healthy volunteers will participate in test-sessions on 4 separate days over approximately 2 weeks.
During the study participants will be randomised into and either a control group (injection of isotonic saline into a neck muscle) or neck pain group (injection of Nerve Growth Factor (NGF) into a neck muscle).
Alle participants tested with regards to:
Brain activity related to neck muscles will be estimated using TMS Balance will be tested using a force place Body movements will be recorded using 3D tracking Muscle activity will be estimated using electromyography (EMG)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men and women aged 18-50 years
- •Only for sub-projects 1 and 2: Right-handed
- •Able to speak, read and understand Danish and English
排除标准
- •Pain from the neck or shoulder area during the past 6 months
- •Experience of delayed onset muscle soreness (DOMS) during the week leading up to the test session
- •Former surgery in neck or shoulder
- •Current or previous chronic or recurrent pain condition
- •Pregnancy
- •Drug addiction defined as the use of cannabis, opioids or other drugs
- •Previous neurologic, musculoskeletal or mental illnesses
- •Regular use of analgesics
- •Abnormally disrupted sleep in the last 24 hours preceding the experiment
- •Lack of ability to cooperate
- •Unable to pass the TASS safety screening questionnaire for TMS
结局指标
主要结局
Change in pressure pain threshold (PPT) measured with a handheld pressure algometer
时间窗: Day 0, 2,4 and 15
PPT will be assessed over head, neck, arm and leg sites.
Change in motor evoked potentials
时间窗: Day 0, 4 and 15
Trans cranial magnetic stimulation (TMS) is used to asses motor evoked potentials of neck muscles
Change in Body movement
时间窗: Day 0, 4 and 15
3D recordings of body movements
次要结局
- The Big Five Inventory (BFI)(Day 2)
- Change in standing balance(Day 0, 4 and 15)
- Disability(Day 0, 2,4 and 15)
- Pain Catastrophizing Scale (13 item questionnaire)(Day 2)
- Change in muscle activity (EMG)(Day 0, 4 and 15)
- Change in perceived pain: McGill Pain Questionnaire(Day 0, 2,4 and 15)
研究者
Steffan Wittrup Christensen
Assistant professor
Aalborg University