Intensive blood glucose control for chronic obstructive pulmonary disease (COPD) patients on acute medical wards
Completed
- Conditions
- Acute exacerbation of chronic obstructive pulmonary disease (AECOPD)RespiratoryOther chronic obstructive pulmonary disease
- Registration Number
- ISRCTN42412334
- Lead Sponsor
- St George's, University of London (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
1. Physician diagnosis of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) as primary cause for admission
2. Able to enter study within 24 hours of admission
3. Age greater than 40 years, male and female
Exclusion Criteria
1. Intensive care unit admission
2. Moribund or not for active treatment
3. Admission expected to last less than 48 hours
4. Unable or unwilling to give informed consent
5. Known type I diabetes mellitus
6. Patients with reduced awareness of hypoglycaemia including reduced Glasgow Coma Scale or those taking beta blockers
6. Patients with renal or hepatic failure at increased risk of hypoglycaemia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The frequency of severe hypoglycaemia - neuroglycopaenic symptoms (other than mild agitation) responsive to administration of carbohydrate. The outcomes are measured/looked for continuously during treatment/hospital stay.
- Secondary Outcome Measures
Name Time Method 1. The frequency of symptomatic hypoglycaemia (capillary glucose less than or equal to 3.3 mM and symptoms consistent with hypoglycaemia)<br>2. The frequency of asymptomatic hypoglycaemia (capillary glucose less than or equal to 3.3 mM without any symptoms consistent with hypoglycaemia)<br>3. Mean 24 hour capillary glucose concentrations<br>4. Proportion of capillary glucose measurements in target range (4.4 - 6.5 mM)<br>5. Comparison of capillary blood glucose measurements to those obtained from the Guardian REAL®-time continuous glucose monitoring system<br>6. Comparison of rates of detection of hypoglycaemia by capillary and continuous blood glucose monitoring<br>7. Quantification of acceptability of the study intervention to patients <br><br>The outcomes are measured/looked for continuously during treatment/hospital stay.