500NL project

Completed

• Conditions: Autoimmuunziekten; Infectious diseases and autoimmune diseases; 10021460; 10019815

• Registration Number: NL-OMON37251
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 1500

Inclusion Criteria

healthy volunteers (n=500):
- older than 18 years
- no chronic or acute disease at the time of assessment
- no use of chronic or acute medication at the time of the study
Inclusion criteria for the patient groups:;RVVC patients (n=200)
- healthy women, age >18 years
- no pregnancy, no diabetes, no antibiotic use
- at least 3 episodes of vulvo-vaginal candidiasis per year, microbiologically confirmed;Candidemia patients (n=50)
- patient with blood culture positive for a Candida species
- age > 18 years
- treatment given no longer than 24h before sample collection;Lyme disease patients (n=150)
- age > 18 years old
- clinical diagnosis based on erythema migrans.
- positive serology (IgG) for Borrelia. ;Gout patients (n=200)
- age > 18 years
- diagnosis based on clinical criteria and positive urate crystals in the joint fluid;HIV-infected patients (n=400)
- age > 18 years
- HIV infection based on viral loads and CD4 counts
- no opportunistic infection at the time of sampling

Exclusion Criteria

Pregancy
Age<18 years

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Metadata: Lifestyle questionnaires<br /><br>DNA: Gene polymorphisms at DNA level<br /><br>Microbiome: Presence of groups of bacteria<br /><br>Phenotype: Specific populations of cells<br /><br>Functional data: Cytokine production</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Niet van toepassing</p><br>