Searching for Explanations for Cryptogenic Stroke in the<br>Young: Revealing the Etiology, Triggers, and Outcome
- Conditions
- infarctionischemic stroke100075211000751010007963
- Registration Number
- NL-OMON43346
- Lead Sponsor
- Helsinki University Central Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 60
Ischemic stroke
Age 18 - 49 years
Hospitalized due to first-ever imaging postive ischemic stroke without cause found after complete and timely minimum diagnostic testing
Baseline mandatory minimum tests not obtained in the first week following stroke onset,
including:
a. Brain MRI
b. Routine blood tests, including complete blood count with differential, CRP, fasting glucose,
creatinine, aPTT, INR, total cholesterol, LDL-cholesterol, HDL-cholesterol, HbA1C, and
hemoglobin electrophoresis in individuals of African origin
Other baseline mandatory minimum tests not obtained within the first two weeks following
stroke onset, including:
a. Imaging of cervicocephalic arteries by CTA, MRA, or DSA
b. Transesophageal (highly recommended) and/or transthoracic echocardiography (N.B. Early
screening of venous thrombosis in the lower extremities is highly recommended in patients
with established right-to-left shunt)
c. 24-hour Holter monitoring (or continuous in-hospital ECG monitoring for at least 24 h)
d. Screening for thrombophilia, including anticardiolipin antibodies, lupus anticoagulant, anti-β2-
glycoprotein antibodies, factor V mutation (or aPC resistency ruled out), factor II mutation,
homocysteine, antithrombin III, protein C, and protein S. It is highly recommended to retest
any abnormal finding >12 weeks from the initial testing or >4 weeks after cessation of
anticoagulation at any later time point.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method