Camparison Effects of Autologous Conditioned Serum, platelet rich plasma and Prolotherapy in treatment of Knee osteoarthritis
Phase 3
- Conditions
- Knee osteoartritis.Osteoarthritis of knee
- Registration Number
- IRCT20100720004422N6
- Lead Sponsor
- Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
Age between 40-75
Grade I-II-III of OA (Kellgren-Lawrence)
Pain severity >4 in a 10-numbered linear scale
Pain in more than 3 months
Exclusion Criteria
Grade IV of OA
Multifactorial Knee Pain
Lower limb Deformity
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Functional condition. Timepoint: At the beginning of the study(before the intervention) ? one and six months after treatment. Method of measurement: Western Ontario and McMaster (WOMAC) questionair.;Pain severity. Timepoint: Visual Analogue Scale (VAS) and Western Ontario and McMaster (WOMAC) questionnaire. Method of measurement: At the beginning of the study(before the intervention) and one and six months after treatment.
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie the anti-inflammatory effects of autologous conditioned serum in knee osteoarthritis?
How does platelet-rich plasma compare to prolotherapy in knee osteoarthritis pain management and cartilage regeneration?
Which biomarkers predict response to autologous conditioned serum versus PRP in knee osteoarthritis patients?
What are the adverse event profiles of autologous conditioned serum, PRP, and prolotherapy for knee osteoarthritis treatment?
Are there combination therapies involving autologous conditioned serum or PRP that improve knee osteoarthritis outcomes compared to monotherapies?