ER2 Frailty Levels and Incident Adverse Health Events in Older Community Dwellers

• Conditions: Aging; Frailty; Emergencies

• Registration Number: NCT04431986
• Lead Sponsor: Jewish General Hospital

Brief Summary

Older adults' health and functional status are heterogeneous because of the various cumulative effects of chronic diseases and physiologic decline, contributing to a vicious cycle of increased frailty 1-4. Thanks to advances in medicine and hygiene, a growing number of older adults spend more years with a greater range of chronic diseases causing disability but not mortality 5. Health systems need to face this new challenge 4,5. Quantification of frailty and its association with the occurrence of incident adverse health events (i.e., functional decline, unplanned hospitalizations) is crucial to understand how health systems may efficiently respond to this situation 6. This study aims to examine the association of the ER2 tool score and its stratification in three levels for incident adverse health events in older community dwellers and to compare this association with three validity frailty indexes which are the Cardiovascular Health Study (CHS) frailty index, Study of Osteoporotic Fracture (SOF) index and Rockwood frailty index.

Detailed Description

Not available

Study Timeline

• Status Verified: 2020-06
• Study First Submitted: 2020-06-11
• Study First Submitted QC: 2020-06-11
• Last Update Submitted: 2020-06-11
• Study First Posted: 2020-06-16
• Last Update Posted: 2020-06-16
• Study Start: 2020-09-01
• Primary Completion: 2021-09-01
• Study Completion: 2021-09-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1741

Inclusion Criteria

• All enrolled participants of NuAge Study who agreed to be part of the NuAge Database and Biobank for future research purposes

Exclusion Criteria

• Missing data
• Participants' refusal to use their data for a purpose not identified during their recruitment.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Physical functional decline	4 years	annual variation of physical functional score available in the Nuage database
Hospitalizations	4 years	presence or absence of hospitalizations, information available in the Nuage database
ER2	4 years	6-item questionnaire determining a stratification of frailty risk in three levels (Low, moderate, high)
SOF index	4 years	index with 3 items determining a level of frailty from 0 (patient is vigorous) to 1 (patient is pre-frail)
CHS index	4 years	index with 5 items determining a level of frailty from 0 component positive (patient is vigorous), 1 or 2 positive components (patient is in an intermediate stage) to 3 or more positive components (patients is frail)
Rockwood index	4 years	index determining a level of frailty from 0 to 17 (less than 5: patient is vigorous, between 6 and 11 patient is apparently vulnerable and above 12 patient is in severe frailty)
Mortality	4 years	death of the participant, information available in the Nuage database
Falls	4 years	presence or absence of falls, information available in the Nuage database