Cognitive Training for Depression
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Major Depressive Disorder
- Sponsor
- Icahn School of Medicine at Mount Sinai
- Enrollment
- 21
- Locations
- 1
- Primary Endpoint
- change in Hamilton Depression Rating Scale (Ham-D)
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
This study is evaluating the effects of two brain training exercises on: memory, cognitive processing and depression symptoms.
Detailed Description
There is an urgent public health need to develop more effective and well tolerated treatments for patients with major depressive disorder (MDD); cognitive training interventions aiming to modify cognitive and affective processing abnormalities underlying MDD represent a promising new strategy. This research project translates a well established cognitive bias in major depressive disorder (MDD), working memory bias, into a novel intervention target. In a double-blind, randomized, controlled study, MDD participants undergo 4 weeks of cognitive training sessions, with two sessions per week.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Primary, current Axis I diagnosis of Major Depressive Disorder according to DSM-IV criteria and Ham-D-17 score between 16-27
- •Age 18-55
- •Able to give informed consent
Exclusion Criteria
- •A history of drug or alcohol abuse or dependence (DSM-IV criteria) within 6 months
- •Visual impairment that would affect the ability to observe the computerized presentation of faces.
- •Motor impairment that would affect the ability to provide a response by quickly pressing a button.
- •Lifetime history of Bipolar spectrum disorders or schizophrenia spectrum disorders.
- •Primary, current Axis I diagnosis other than Major Depressive Disorder
- •Primary, current Axis II personality disorder.
- •Currently attending a cognitive-behavioral psychotherapy regimen
- •Acute suicidal or homicidal risk (evidenced by suicidal or homicidal attempt within 6 months of screening)
- •Pregnancy in women.
- •Subjects must exhibit no or only moderate alcohol use. Subjects with current excessive use of alcohol (\> 8 ounces/day for men and \> 6 ounces/day for women) are ineligible for participation, as such drug use could confound the results.
Outcomes
Primary Outcomes
change in Hamilton Depression Rating Scale (Ham-D)
Time Frame: baseline and week 4
Change in depression symptom severity at week 4 compared as to baseline
Secondary Outcomes
- change in Self-referential Information Processing Task(baseline and week 4)
- change in Working Memory(baseline and week 4)