A comparative study of combined perineural Dexamethasone and Dexmedetomidine versus perineural Dexamethasone alone as adjuvants to Ropivacaine in adductor canal block for postoperative analgesia in patients undergoing total knee arthroplasty.
Not Applicable
- Conditions
- Health Condition 1: M171- Unilateral primary osteoarthritisof knee
- Registration Number
- CTRI/2023/06/053586
- Lead Sponsor
- Tata Main Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients undergoing elective primary unilateral total knee arthroplasty under subarachnoid block
ASA grades I-III
Exclusion Criteria
Patients refusing to participate in the study
History of allergy to local anesthetics
Patients with coagulopathy or infection at the site of block
Patients with psychiatric illness or cognitive dysfunction who cannot use the patient-controlled analgesia (PCA)
Patients having neuromuscular deficits, severe COPD, renal deficiency, severely compromised cardiovascular status
Patients with body mass index (BMI) of > 35 kg/m2
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Total opioid (Morphine) consumption in the first 24 hours postoperativelyTimepoint: Total opioid (Morphine) consumption in the first 24 hours postoperatively
- Secondary Outcome Measures
Name Time Method Episodes of hypotension, bradycardia and desaturation <br/ ><br>Timepoint: In the first 48 hours postoperatively;Functional outcome by TUG test (in seconds)Timepoint: At 48 hours postoperatively <br/ ><br>;NRS pain scoresTimepoint: At 3, 6, 12, 18, 24, 30, 36, 42 and 48 hours postoperatively, both at rest and with movement;Opioid (Morphine) consumptionTimepoint: At 48 hours postoperatively;Quadriceps muscle strength assessment by Manual Muscle Testing score (MMT) <br/ ><br>Timepoint: At 24 and 48 hours postoperatively;Ramsay sedation score <br/ ><br>Timepoint: at 3, 6, 12, 18, 24, 20, 36, 42 and 48 hours postoperatively;Time to first requirement of rescue analgesia <br/ ><br>Timepoint: Not Applicable