Histologic Analysis of Female Urethral Strictures Following Dorsal On lay Buccal Mucosal Graft Urethroplasty
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- a)Evaluation for epithelial hyperplasia and cell type
研究概览
简要总结
There is no literaturewith regard to the histopathology of female urethral stricture diseasecurrently. In a recent study by RamPathak et al of 9 patients who underwent urethroplasty, 67 % of the patients had stratified squamousepithelium overlying fibrosis, while 29% showed acute injury with prominentsquamous papillary hyperplasia. While many studies have looked into the pathophysiologyof Urethral Stricture Disease in males and suggested that chronic inflammationand Lichen’s Sclerosis are the most common findings, there is a huge paucity ofdata with regard to females. Here, we look to present the pathologicanalysis of female urethral stricture disease.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)(—)
- 性别
- Female
入选标准
- •1.Females aged 18 years or above with urethral stricture disease confirmed by uroflowmetry and cystoscopy.
- •2.Females who undergo a dorsal onlay buccal mucosal graft urethroplasty.
- •3.Written informed consent.
排除标准
- •1.Patients who have undergone surgery for urethral stricture disease previously 2.Patients in whom ventral BMGU is performed.
- •3.Patients with STDs 4.Patients with genitourinary anomalies 5.Patients who have had surgery for hypertrophy of the bladder neck 6.Patients who have had radiation to the pelvis 7.Patients with bladder malignancies.
结局指标
主要结局
a)Evaluation for epithelial hyperplasia and cell type
时间窗: 10 days
次要结局
- a)To evaluate the presence of mucosal oedema(b)To evaluate the degree of fibroblast/inflammatory cell infiltrate)
