Glycemic Response of Amylopectin Containing Drinks
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Sponsor
- Arizona State University
- Enrollment
- 15
- Locations
- 1
- Primary Endpoint
- Area Under the Curve of Glucose
Study Overview
Brief Summary
To quantify the glycemic index of the SP energy-smart-based nutrition supplement and the SP Glucose-support formula as compared to a glucose drink. We hypothesized that both the energy-smart-based nutritional supplement and the SP Glucose-support formula will have low glycemic index.
The aim of the study is to quantify the glycemic index of the SP energy-smart-based nutrition supplement and the SP Glucose-support formula as compared to a glucose drink. We hypothesized that both the energy-smart-based nutritional supplement and the SP Glucose-support formula will have low glycemic index.
Detailed Description
Subjects: 9 non-diabetic (HbA1c < 6.5) males aged 30-55 years with body mass indices ranging from 27.5 to 35 kg∙m-2. Individuals with impaired glucose tolerance will be included as long as they are not diagnosed with diabetes and their HbA1c is less than 6.5.
Preliminary Testing: Medical history, weight, height, body composition via dual x-ray absorptiometry (DXA) and glycosylated hemoglobin (HbA1c) measurement.
Protocol: After a 10-hour overnight fast, subjects will complete 3 experimental visits in which they will ingest one of three beverages in a randomized order. During experimental visits subjects will either be given the following 3 experimental drinks:
- Full SP-glucose balance formula (200 kcal)
- Energy smart carbohydrate blend (50 g, 200 kcal)
- Liquid dextrose solution in the form of TRUTOL ® Glucose Tolerance Test Beverage (50 g, 200 kcal)
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 30 Years to 55 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •BMI 27.5 to 35 kg∙m-2
Exclusion Criteria
- •Diagnosed diabetes
- •HbA1c > 6.5
- •competitive athletes
- •body weigh change > 3kg during last month
Arms & Interventions
Standard Process - glucose balance
Standard Process - glucose balance formula (200 kcal)
Intervention: Carbohydrate drink (Dietary Supplement)
Energy smart Carbohydrate blend
Energy smart carbohydrate blend (50 grams, 200 kcal)
Intervention: Energy smart Carbohydrate blend (Dietary Supplement)
Liquid Dextrose Control
Liquid dextrose solution in the form of TRUTOL ® Glucose Tolerance Test Beverage (50 grams, 200 kcal)
Intervention: Liquid Dextrose (Dietary Supplement)
Outcomes
Primary Outcomes
Area Under the Curve of Glucose
Time Frame: 120 minutes
Positive integer of the area under the Curve of glucose
Blood insulin
Time Frame: 30, 60 and 120 minutes of the glucose challenge
Blood insulin levels
Area Under the Curve for Insulin
Time Frame: 120 minutes
Positive integer of the area under the Curve of insulin
Blood glucose
Time Frame: 30, 60 and 120 minutes of the glucose challenge
Blood glucose levels
Secondary Outcomes
- glucagon(30, 60, and 120 minutes of of the glucose challenge)
- glucagon-like-peptide-1(30, 60, and 120 minutes of the glucose challenge)
- Leptin(30, 60, and 120 minutes of the glucose challenge)
- Adiponectin(30, 60, and 120 minutes of the glucose challenge)
- c-peptide(30, 60, and 120 minutes of the glucose challenge)