Intraabdominal Pressure Monitoring Urinary Catheter and Kidney Perfusion Pressure

Not Applicable

Not yet recruiting

• Conditions: Acute Kidney Injury

• Registration Number: NCT06989762
• Lead Sponsor: Dang Tan Phat

Brief Summary

The goal of this clinical trial is to determine whether monitoring intra-abdominal pressure (IAP) and adjusting blood pressure accordingly to maintain optimal renal perfusion pressure can reduce the risk of acute kidney injury (AKI) after cardiac surgery.

The main question this study aims to answer is:

- Does IAP-guided blood pressure management improve renal perfusion and lower AKI rates in cardiac surgery patients?

Participants will be randomly assigned to one of two groups:

* Control Group: Standard ICU care with a conventional Foley catheter.

* Intervention Group: Standard ICU care with an IAP-monitoring Foley catheter, where blood pressure is adjusted based on IAP readings to optimize renal perfusion pressure.

All participants will undergo routine blood and urine tests to assess kidney function during their hospital stay.

This study will help determine whether IAP-based hemodynamic management can improve postoperative kidney outcomes and provide a new strategy for AKI prevention in cardiac surgery patients.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-04
• Study First Submitted: 2025-04-15
• Study First Submitted QC: 2025-05-22
• Study First Posted: 2025-05-25
• Last Update Submitted: 2025-06-26
• Last Update Posted: 2025-07-01
• Study Start: 2025-08-01
• Primary Completion: 2027-06-01
• Study Completion: 2027-10-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Adults Undergoing cardiac surgery with cardiopulmonary bypass
• Left ventricular ejection fraction (LVEF) < 50%

Exclusion Criteria

• Current pregnancy
• ESRD or AKI on dialysis
• Currently on ECMO or Impella
• Emergent surgery

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Incidence of Postoperative Acute Kidney Injury (AKI) as defined by KDIGO Criteria	Perioperative.	Acute Kidney Injury will be defined using the KDIGO criteria: an increase in serum creatinine by ≥0.3 mg/dL within 48 hours or an increase to ≥1.5 times the baseline.

Secondary Outcome Measures

Name	Time	Method
ICU Length of Stay	Perioperative	The number of days from the day of surgery until discharge from the ICU
Hospital Length of Stay	Perioperative	The number of days from the day of surgery until discharge from the hospital (including both ICU and general ward)

Trial Locations

Locations (1)

UCI Medical Center; 🇺🇸 Irvine, California, United States