The effect of intravenous pre-emptive versus postoperative paracetamol on postoperative nausea and vomiting in patients undergoing strabismus surgery: A prospective randomised study

Phase 4

Completed

• Conditions: postoperative nausea and vomiting; strabismus surgery; Anaesthesiology - Pain management

• Registration Number: ACTRN12616000672459
• Lead Sponsor: Mehmet AKSOY

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-05-23
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Ninety-six patients, between the ages of 2 and 14 years,ASA (the classification of the American Society of Anesthesiologists) physical status I-II who underwent elective strabismus surgery under general anaesthesia were included

Exclusion Criteria

Patients with a history of allergy to any of the study medications (general anesthetic agents or paracetamol), with a history of previous PONV or motion sickness, hepatic or renal disease, use of antiemetic, antihistaminic, analgesic or corticosteroid 24 hours prior to surgery and were excluded from the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome of the study was the incidence of nausea during the first 24 hours postoperatively. Nausea defined as retching and it was assessed by self-report by child in symptom diary.[postoperative 0-6, 6-12 and 12-24 hours.];The primary outcome of the study was the incidence of vomiting during the first 24 hours postoperatively. Vomiting was defined as a forceful expulsion of the gastric contents through the mouth or the nose. and it was assessed by self-report by child in symptom diary.[Postoperative 0-6, 6-12 and 12-24 hours.]

Secondary Outcome Measures

Name	Time	Method
the need for rescue analgesic during 24 hours postoperatively via reviewing of medical records.[Postoperative 0-6, 6-12 and 12-24 hours.];the need for antiemetic requirement during 24 hours postoperatively via reviewing of medical records.[postoperative 0-6, 6-12, 12-24 hours.];Faces Pain Scale score via reviewing of medical records.[Every hour whilst awake from arrival in recovery room to 24 hours post-operatively. ]