Evaluation of the effects of topical application of oral care agents on white spots in enamel in healthy adults
- Conditions
- dental cariesenamel demineralizationOral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon
- Registration Number
- ACTRN12622001258741
- Lead Sponsor
- niversity of Melbourne
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 4
Inclusion Criteria
Age range: 18 to 75 years.
Gender: Males and females.
Good general health.
At least 22 natural teeth
A gum- stimulated whole salivary flow rate at least 1.0 ml/minute and unstimulated whole salivary flow rate at least 0.2 ml/minute.
Available for both treatment periods.
The exclusion criteria include:
1) History of adverse or allergic reactions to milk proteins (such as casein), tin or tin-containing products, or any other ingredients in the
products;
2) Orthodontic appliances or removable dentures;
3) Veneers, or more than one incisor with an artificial crown;
4) Oral diseases including advanced periodontal disease;
5) Chronic disease such as diabetes or use of medications that cause gum swelling;
6) Untreated decay;
7) Treatment with antibiotics or anti-inflammatory medicines in the month prior to starting the study;
8) Use of drugs that may interact with the toothpaste slurries or which may affect salivary flow rate;
9) History of health conditions requiring antibiotic coverage prior to dental treatment;
10) Pregnancy/lactation;
11) Serious infectious disease;
12) Any other medical or dental condition deemed to put the health and wellbeing of you or the research team at risk if you participated in
the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Any change in white spots lesions in enamel slabs measured using image analysis of standardized photographs of the white spots.[<br>Baseline before intervention, and 14 days post-intervention commencement.<br>]
- Secondary Outcome Measures
Name Time Method Any change in the mineralisation content of white spots lesions in enamel slabs measured by calculating the difference in mineral content of lesions exposed to the oral care agents, using microdensitometric analysis of microradiographic images of the lesions.[<br>Baseline before intervention, and 14 days post-intervention commencement.<br>]