NCT04552444Unknown不适用
Clinical Efficacy of Combination Therapy Based on High-dose Biapenem in CRKP Infections
Second Affiliated Hospital, School of Medicine, Zhejiang University1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2019年6月1日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- 28-day mortality
研究概览
简要总结
Carbapenem resistance is a high mortality rate of Klebsiella pneumoniae infection. It has been proved that high-dose carbapenem can reduce mortality and has a certain clinical effect. In this study, a high dose of biapenem was compared to determine whether it had a similar effect than meropenem.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 14 Years 至 100 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ICU hospitalized for more than 3 days;
- •Biapenem used for more than 3 days
排除标准
- •Patients who refuse to be included in the group or pregnant women or under the age of 14 or ICU hospitalized for less than 3 days
研究组 & 干预措施
the death group
Through the corresponding treatment, the patients who died within 28 days
干预措施: Biapenem (Drug)
the survival group
Through the corresponding treatment, the patients who survived within 28 days
干预措施: Biapenem (Drug)
结局指标
主要结局
28-day mortality
时间窗: 2017.01.01-2021.12.31
次要结局
- Clearance rate of pathogenic microorganisms(2017.01.01-2021.12.31)
- ICU hospitalization days(2017.01.01-2021.12.31)
研究者
Man Huang, Ph.D
Sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University
研究点 (1)
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