Translational Research of Inflammatory Bowel Disease in Korea
- Conditions
- Diseases of the digestive system
- Registration Number
- KCT0000545
- Lead Sponsor
- Asan Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 7500
Crohn' disease: patients who met at least 2 of the following criteria
a) clinical history of abdominal pain, weight loss, malaise, diarrhea,
and/or rectal bleeding; b) endoscopic findings of mucosal
cobblestoning, linear ulceration, skip areas, or perianal disease;
c) radiologic findings of stricture, mucosal
cobblestoning, or ulceration; d) macroscopic appearance of
bowel wall induration, mesenteric lymphadenopathy, and
creeping fat” at laparotomy; and e) pathologic findings of
transmural inflammation and/or epithelioid granulomas. Only
patients who met these criteria for at least 2 months are
included.
- Ulcerative colitis: patients who met all 3 of the following criteria
a) a typical history of diarrhea or blood and pus or both in the stool for longer than 4 weeks; b) a typical sigmoidoscopic or colonoscopic
picture with diffusely granular, friable, or ulcerated mucosa
without rectal sparing or skip lesions or radiological signs of
characteristic continuous granular or ulcerated mucosa; and
c) characteristic histopathological signs of inflammation on
biopsy.
- Controls: subjects who do not have any evidence of inflammatory bowel disease and who gave an informed consent for being enrolled in this study
- IBD unclassified
- Younger than 15 years
- Not Korean ethnicity
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical features and prognosis of Korean patients with inflammatory bowel disease;Serologic biomarker: ASCA, pANCA, Anti-I2, Anti-OmpC, Anti-CBir1;Genome wide association study and analysis;Illumina exome array
- Secondary Outcome Measures
Name Time Method Clinical and genetic prognostic markers