Algorithm to Quantitatively Determine the Ideal Drug Dose to Treat Attention Deficit Hyperactivity Disorder
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 46
- 试验地点
- 1
- 主要终点
- Reaction time
研究概览
简要总结
The goal of this study is to create a formal, quantitative methodology to determine what is the most beneficial dose of Central Nervous System (CNS) stimulant (Ritalin, methylphenidate) to improve cognitive and behavioral function of children diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) individually. If successful, it will change the way in which the dose of CNS stimulant for treating ADHD is determined for children in need of therapeutic intervention. The project will be focused on developing the necessary methodology to analyze the children's data with the drift-decision model (DDM), and to develop the required technology, i.e., a computer game with which to measure cognitive/behavioral function and its validation with eye-tracking measurements.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 8 Years 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •8-12 years of age;
- •Accompanied by caregiver (parent or legal guardian);
- •Able to understand and speak English;
- •Able to read basic English;
- •No counseling or current/past history of psychiatric illness, as confirmed by the Child Behavior Checklist (CBCL) and Conner's rating scale
排除标准
- •Active psychosis or suicidality
- •History of primary psychotic disorder (e.g., schizophrenia) or bipolar disorder
- •Recent (past 2 weeks) substance abuse or dependence
- •History of brain damage or significant developmental delay
- •Unstable medical condition such as newly diagnosed Type I Diabetes or Rheumatoid arthritis
- •Use of oral steroids
- •Participation in the last 30 days in a clinical study involving an investigational drug
- •Current use of a psychotropic medicine
结局指标
主要结局
Reaction time
时间窗: At the time of testing (the investigators are measuring acute effects, not following outcomes based on a treatment)
The investigators record how long it took them to make their choices.
Task choice
时间窗: At the time of testing (the investigators are measuring acute effects, not following outcomes based on a treatment)
Subjects will perform different cognitive tasks and we will record their choices.
Eye position
时间窗: At the time of testing (the investigators are measuring acute effects, not following outcomes based on a treatment)
The tasks are eye movement based. The investigators record where the subjects were looking as voltages, which are converted to x/y coordinates through a calibration, throughout the different events of the task.
次要结局
未报告次要终点