Bone - MRI in Renal Insufficiency
Withdrawn
- Conditions
- End Stage Renal DiseaseHyperoxaluria100132961000595910029149
- Registration Number
- NL-OMON38866
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 45
Inclusion Criteria
ESRD on dialysis or after renal transplantation OR
hyperoxaluria, AND
age >8 years
Exclusion Criteria
* Any co-morbidity causing bone disease, such as osteogenesis imperfecta, Marfan syndrome, Ehler Danlos, panhypopituitarism, malignancy and musculoskeletal disorders
* Inability to perform adequate MR imaging, for example not being able to lie still
* absolute contra-indications for MR imaging, such as metal in eyes, cardiac pacemakers, implanted cardioverter defibrillators, neurostimulation systems and cochlear implants
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary objectives:<br /><br>- To asses the validity of microMRI in imaging trabecular and cortical bone<br /><br>- To asses the feasibility to diagnose ROD in pediatric ESRD with microMRI in<br /><br>an early stage<br /><br>- To asses the feasibility to diagnose oxalosis associated bone disease with<br /><br>microMRI</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary objectives<br /><br>- To investigate the possibility to distinguish between high and low turnover<br /><br>bone disease in pediatric ESRD with microMRI<br /><br>- Compare microMRI with conventional radiography and/or DEXA scanning in<br /><br>children with ESRD<br /><br>- Compare microMRI with conventional radiography and/or DEXA scanning in<br /><br>patients suffering from oxalosis<br /><br>- Compare microMRI with pathological changes found in bone biopsies from adult<br /><br>ESRD patients who have clinical indication for bone biopsy</p><br>