Effect of Adding a Diet With Low Glycemic Index and Load During 12 Weeks for the Treatment of Moderate Acne in Adults: a Randomized Clinical Trial
Overview
- Phase
- Not Applicable
- Intervention
- Normal diet
- Conditions
- Acne Vulgaris
- Sponsor
- Centro Dermatológico Dr. Ladislao de la Pascua
- Enrollment
- 52
- Primary Endpoint
- Count of inflammatory acne lesions
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Clinical trial to determine the effect of adding a diet with low glycemic index and load to adults for the treatment of moderate acne. Adult patients with acne where recruited in two groups, A and B. Group A received a normal diet according to their metabolic status and group B received a diet with low glycemic index and load. Outcomes were measured at week 12.
Detailed Description
Clinical trial to determine the effect of adding a diet with low glycemic index and load to adults for the treatment of moderate acne. Adult patients with acne where recruited in two groups, A and B. Both groups of treatment were treated with doxycycline 100 mg per day plus adapalene 0.1% gel daily for 12 weeks. During pharmacologic treatment, all patients had nutrition counseling monthly. Group A received a normal diet according to their metabolic status and group B received a diet with low glycemic index and load. At the end of the trial, the change in acne lesions count was analyzed and also their metabolic status. Quality of life was also measured.
Investigators
Dra. Martha Alejandra Morales Sánchez
MD
Centro Dermatológico Dr. Ladislao de la Pascua
Eligibility Criteria
Inclusion Criteria
- •Having moderate inflammatory acne
- •18 to 25 years old
- •Stable weight during the last 3 months
Exclusion Criteria
- •Previous or actual isotretinoin therapy
- •Antibiotic therapy or during the last 3 months
- •Therapy based on peelings, dermabrasion, laser or intense pulsed light during the last 6 months
- •Endocrine disorders
- •Drug and alcohol consumption during the last 6 months
- •Tabacco use during the last 6 months
- •Lactose intolerance
- •Have eating disorders or gastrointestinal disorders
- •Actual nutrition therapy
- •Have chronic diseases that requires pharmacologic therapy
Arms & Interventions
Normal Diet
Participants will receive a normal diet according to their metabolic status.
Intervention: Normal diet
Normal Diet
Participants will receive a normal diet according to their metabolic status.
Intervention: Adapalene 0.1% Gel
Normal Diet
Participants will receive a normal diet according to their metabolic status.
Intervention: Doxycycline
Low glycemic diet
Participants will receive a low-glycemic index and load diet according to their metabolic status. Milk and vitamin supplements will be eliminated from the diet.
Intervention: Low glycemic diet
Low glycemic diet
Participants will receive a low-glycemic index and load diet according to their metabolic status. Milk and vitamin supplements will be eliminated from the diet.
Intervention: Adapalene 0.1% Gel
Low glycemic diet
Participants will receive a low-glycemic index and load diet according to their metabolic status. Milk and vitamin supplements will be eliminated from the diet.
Intervention: Doxycycline
Outcomes
Primary Outcomes
Count of inflammatory acne lesions
Time Frame: 12 weeks
Number of papules and pustules
Secondary Outcomes
- Count of non-inflammatory acne lesions(12 weeks)
- Changes in quality of life(12 weeks)