The tolerance to RISA root canal fluid determined in an in-vivo study

• Conditions: Apical periodontitis, pain

• Registration Number: NL-OMON25853
• Lead Sponsor: ACTA Dental Research B.V.

Brief Summary

1: van der Waal SV, Scheres N, de Soet JJ, Wesselink PR, Crielaard W. Cytotoxicity, interaction with dentine and efficacy on multispecies biofilms of a modified salt solution intended for endodontic disinfection in a new in vitro biofilm model. Int Endod J. 2015; 48:153-61. <br> <br> 2: van der Waal SV, Jiang LM, de Soet JJ, van der Sluis LW, Wesselink PR, Crielaard W. Sodium chloride and potassium sorbate: a synergistic combination against Enterococcus faecalis biofilms: an in vitro study. Eur J Oral Sci. 2012

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

apical periodontitis has been diagnosed and confirmed with an intra-oral radiograph and appears on the radiograph as a radiolucent area around one or more root tips of the affected tooth. A root canal treatment has a reasonable/good prognosis (Sjögren et al. 1990) and the subject prefers NSRCT over tooth extraction or monitoring. The affected tooth has not previously received a complete root canal treatment.

- no spontaneous pre-operative pain or spontaneous pre-operative pain less than 36 (see fig. 1) (Heft & Parker 1984)

Exclusion Criteria

- pain >36 on Heft-Parker VAS scale (fig. 1)

- subject tooth with a mobility score 2 or more

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
pain / no pain

Secondary Outcome Measures

Name	Time	Method
healing apical periodontitis