Examine the effects of combined high-intensity endurance and strength training in children, adolescents, and young adults undergoing hematologic stem cell transplantation.

Not Applicable

Recruiting

Conditions: Z94.81
Z94.80

Registration Number: DRKS00025995

Lead Sponsor: niversitätsklinikum Ulm, Kliniken am Michelsberg

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 36

Inclusion Criteria

Female/Male
HSCT Therapy
Age: 8-25 years
Signed consent form of the participants or legal representatives

Exclusion Criteria

Concomitant diseases that make training impossible
pregnancy
other factors that severely limit the ability to cooperate (highly impaired communication, serious psychiatric illnesses, etc.)

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. quality of life: physical, emotional, social and educational functioning (PedsQL).<br>2. physical performance with endurance (VO2peak, Pmax) and motor performance (coordination, flexibility and strength).

Secondary Outcome Measures

Name	Time	Method
3. length of hospital stay: number and duration of inpatient stay.<br>4. stress echocardiography: (LV FS, LV EF, LVIDd, LVIDs and strain values of the left ventricle: GLS, a4c LS, a3c LS, a2c LS, SAX CS)<br>5. physical activity: step count recording via a wrist movement tracker<br>6. (Re-)integration in physical education (school, club)<br>7. training monitoring data: lactate, heart rate, subjective exertion level, cancer-related fatigue, subjective health status<br>8. occurrence/severity of concomitant diseases (toxicity, infection, GvHD)<br>9. anthropometry: height, body weight, body fat percentage, waist to height ratio (WHtR)<br>10. biomarkers: pro- and anti-inflammatory factors: IGF-1, PGC1-a, protein kinase A, mTOR, MIF, kynurenine, p53, IL10, TNF-alpha.<br>11. course of blood parameters: Platelets, hematocrit, hemoglobin, C-reactive protein, lymphocytes (T cells, B cells, Nk cells).