CTRI/2019/07/020170
Not yet recruiting
Phase 3
EFFECT OF RESPIRATORY PHYSIOLOGICAL CHANGES ON INTRACRANIAL PHYSIOLOGY; OPTIC NERVE SHEATH DIAMETER (ONSD) AND CEREBRAL OXYGEN SATURATION (rScO2) IN ACUTE TRAUMATIC BRAIN INJURY (TBI)
ational Institute of Mental Health and Neurosciences0 sites0 target enrollmentTBD
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- ational Institute of Mental Health and Neurosciences
- Status
- Not yet recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age \> 18 years
- •Patients admitted to ICU \< 72 hrs of acute TBI
- •Patients with baseline requirements of FiO2 \<\= 50% and PEEP \<\= 5 cm H2O
- •Haemodynamic stability
- •Focal lesion in the brain
Exclusion Criteria
- •Age \<\= 18 years
- •Patients with supra\-normal requirements of FiO2 and PEEP
- •Patients with ophthalmological conditions (glaucoma or eye trauma)
- •Conditions where rScO2 measurement using NIRS may be unreliable
- •Conditions with persistent midline shift more than pre\-op status
- •Baseline ONSD \> 6 mm
- •Baseline rScO2 \< 50%
Outcomes
Primary Outcomes
Not specified
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