Bevacizumab, Sorafenib Tosylate, and Temsirolimus in Treating Patients With Metastatic Kidney Cancer
- Conditions
- Clear Cell Renal Cell CarcinomaRecurrent Renal Cell CarcinomaStage IV Renal Cell Cancer AJCC v7
- Interventions
- Biological: BevacizumabOther: Laboratory Biomarker AnalysisOther: Pharmacological Study
- Registration Number
- NCT00378703
- Lead Sponsor
- National Cancer Institute (NCI)
- Brief Summary
This randomized phase II trial studies different combinations of bevacizumab, temsirolimus, and sorafenib tosylate to see how well they work compared with bevacizumab alone in treating patients with kidney cancer that has spread to other places in the body. Monoclonal antibodies, such as bevacizumab, may interfere with the ability of tumor cells to grow and spread. Bevacizumab and sorafenib tosylate may stop the growth of tumor cells by blocking blood flow to the tumor. Temsirolimus and sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving different combinations of bevacizumab, sorafenib tosylate, and temsirolimus may be more effective than bevacizumab alone in treating metastatic kidney cancer.
- Detailed Description
PRIMARY OBJECTIVES:
I. To assess progression-free survival on each arm of combination targeted therapy (CTT) compared to that of bevacizumab alone.
SECONDARY OBJECTIVES:
I. To assess the significance of changes in tumor size over early time points as a predictor of progression-free survival (PFS).
II. To quantify the number and percent of patients who have stable disease at 6 months of therapy (failure to progress) in each treatment arm of CTT in patients with metastatic renal cell carcinoma (RCC).
III. To evaluate the safety of each treatment arm of combination targeted therapy (CTT) in patients with metastatic RCC.
IV. To assess overall survival in each arm of the study. V. To assess the objective response rate in each treatment arm of CTT in patients with metastatic RCC.
VI. To assess pathology, angiogenesis histology and to assess activation status of mitogen activated protein (MAP) kinase and vascular endothelial growth factor receptor 2 (VEGFR2) pathways and relate to clinical outcome.
TERTIARY OBJECTIVES:
I. To analyze the pharmacokinetic and pharmacogenetic properties of sorafenib (sorafenib tosylate) including angiogenesis, monooxygenases polymorphisms and multi-drug resistance (MDR).
II. To relate changes in tumor perfusion and vascular permeability on serial dynamic contrast-enhanced magnetic resonance imaging (MRI) to clinical outcome and radiologic regression detected by other standard methods.
III. To assess the potential of dynamic contrast-enhanced (DCE)-MRI imaging as a biomarker for response to therapy and/or as a prognostic indicator of disease progression.
IV. To assess site readiness and ability in acquiring DCE-MRI data. V. To determine the relationship between tumor and blood biomarkers and clinical outcomes of patients treated with the combination of targeted agents.
OUTLINE: Patients are randomized to 1 of 4 treatment arms.
ARM A: Patients receive bevacizumab intravenously (IV) over 30-90 minutes on days 1 and 15.
ARM B: Patients receive temsirolimus IV over 30 minutes on days 1, 8, 15, and 22 and bevacizumab as in Arm A.
ARM C: Patients receive bevacizumab as in Arm A and sorafenib tosylate orally (PO) twice daily (BID) on days 1-5, 8-12, 15-19, and 22-26.
ARM D: Patients receive sorafenib tosylate PO BID on days 1-28 and temsirolimus as in Arm B.
In all arms, courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up periodically for 5 years.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 361
-
Patients will be required to have the clear cell variant of renal cell carcinoma with less than 25% of any other histology (including, but not limited to, papillary or chromophobe or oncocytic); there must be histologic confirmation by treating center of either primary or metastatic lesion
-
Patients will be required to have measurable metastatic disease that is not curable by standard radiation therapy or surgery; all sites must be assessed within 4 weeks prior to study entry
-
Previous nephrectomy is required with the following exceptions:
- Primary tumor =< 5 cm, or
- Extensive liver (> 30% of liver parenchymal) or multiple (> 5) bone metastases, making nephrectomy a clinically questionable procedure
- Unresectable primary tumor due to invasion into adjacent organs or encasing the aorta or vena cava
-
No prior cytotoxic chemotherapy; a maximum of one prior regimen of either vaccine or cytokine-based immunotherapy disease is permitted
-
No prior anti-angiogenic therapy including, but not limited to, SU11248, ZD6474 or VEGF Trap; no prior therapy with bevacizumab, mammalian target of rapamycin (mTOR) inhibitors (including, but not limited to, temsirolimus), or sorafenib will be allowed; thalidomide or interferon alpha (IFNalpha) are allowed either for adjuvant therapy or stage IV disease
-
No immunotherapy within 4 weeks of randomization; toxicities from immunotherapy must have resolved and a minimum of two weeks must pass prior to enrollment
-
Prior radiation therapy is permitted, but toxicities from radiation must have resolved and a minimum of 2 weeks must pass prior to randomization
-
No history or clinical evidence of central nervous system (CNS) disease, including primary brain tumor, seizures not controlled with standard medical therapy, any brain metastasis, or history of stroke within the past 48 weeks
-
Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
-
Life expectancy of greater than 12 weeks
-
Hemoglobin (Hgb) >= 9.0 g/dL (transfusions allowed prior to enrollment)
-
White blood count (WBC) >= 3,000/mm^3
-
Absolute granulocyte count (AGC) >= 1,200/mm^3
-
Platelet count >= 100,000/mm^3
-
Serum creatinine =< 1.5 x upper limit of normal (ULN) or serum creatinine clearance (CrCl) >= 55 ml/min
-
Total bilirubin =< 1.5 x ULN
-
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x ULN (or =< 5.0 x ULN in the presence of liver metastases)
-
International normalized ratio (INR) =< 1.5
-
Activated partial thromboplastin time (aPTT) within normal limits
-
Fasting cholesterol < 350 mg/dL (9.0 mmol/L)
-
Fasting triglycerides < 400 mg/dL (4.56 mmol/L)
-
Patients must not have other current malignancies, other than basal cell skin cancer, squamous cell skin cancer, in situ cervical cancer, and ductal or lobular carcinoma in situ of the breast; patients with other malignancies are eligible if they have been continuously disease-free for >= 5 years prior to the time of randomization
-
No history of allergic reactions attributed to Chinese hamster ovary cell products, other recombinant human antibodies, or compounds of similar chemical or biologic composition to sorafenib, temsirolimus or bevacizumab
-
No history of bleeding diathesis or coagulopathy
-
Any condition that impairs patient's ability to swallow pills will make patient ineligible
-
No major surgical procedure, open biopsy or significant traumatic injury within 28 days prior to randomization
-
No anticipated need for major surgery during the course of the study
-
No current or recent (within 4 weeks of enrollment) use of full-dose of anticoagulants or thrombolytic agents (except as required to maintain patency of preexisting or permanent indwelling IV catheters, for those patients receiving warfarin, INR must be =< 1.5)
-
No clinically significant cardiovascular disease, defined as one of the following:
- Patients with uncontrolled hypertension (blood pressure > 150/100 mm/Hg at the time of enrollment); patients with hypertension and blood pressure =< 150/100 mm/Hg on stable antihypertensive regimen are eligible
- Myocardial infarction or unstable angina < 24 weeks prior to registration
- New York Heart Association grade II or greater congestive heart failure, serious cardiac arrhythmia requiring medication, unstable angina pectoris
- Grade II or greater peripheral vascular disease
-
No serious, non-healing wound, ulcer, or bone fracture
-
No significant proteinuria at baseline; urine protein must be screened within 2 weeks prior to randomization by urine analysis for urine protein creatinine (UPC) ratio; if UPC ratio is > 0.5, 24-hour urine protein is to be obtained and the level must be < 1000 mg for patient enrollment
- NOTE: UPC ratio of spot urine is an estimation of the 24 urine protein excretion; a UPC ratio of 1 is roughly equivalent to a 24-hour urine protein of 1 gm
-
No uncontrolled intercurrent illness including, but not limited to, ongoing or active infection requiring parenteral antibiotics on day 0 or psychiatric illness/social situations that would limit compliance with study requirements
-
Patients currently taking any of the following cytochrome P450 enzyme-inducing drugs are ineligible:
- Phenytoin
- Carbamazepine
- Phenobarbital
- Rifampin
-
Pregnant and breastfeeding women are excluded from the study; breastfeeding should be discontinued while receiving therapy; patients must have pregnancy test within 7 days prior to patient randomization if woman is of child-bearing capacity
-
Human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the study
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Arm A (bevacizumab) Bevacizumab Patients receive bevacizumab IV over 30-90 minutes on days 1 and 15. Arm A (bevacizumab) Laboratory Biomarker Analysis Patients receive bevacizumab IV over 30-90 minutes on days 1 and 15. Arm A (bevacizumab) Pharmacological Study Patients receive bevacizumab IV over 30-90 minutes on days 1 and 15. Arm D (sorafenib tosylate and temsirolimus) Laboratory Biomarker Analysis Patients receive sorafenib tosylate PO BID on days 1-28 and temsirolimus as in Arm B. Arm B (bevacizumab and temsirolimus) Bevacizumab Patients receive temsirolimus IV over 30 minutes on days 1, 8, 15, and 22 and bevacizumab as in Arm A. Arm B (bevacizumab and temsirolimus) Laboratory Biomarker Analysis Patients receive temsirolimus IV over 30 minutes on days 1, 8, 15, and 22 and bevacizumab as in Arm A. Arm B (bevacizumab and temsirolimus) Pharmacological Study Patients receive temsirolimus IV over 30 minutes on days 1, 8, 15, and 22 and bevacizumab as in Arm A. Arm B (bevacizumab and temsirolimus) Temsirolimus Patients receive temsirolimus IV over 30 minutes on days 1, 8, 15, and 22 and bevacizumab as in Arm A. Arm D (sorafenib tosylate and temsirolimus) Pharmacological Study Patients receive sorafenib tosylate PO BID on days 1-28 and temsirolimus as in Arm B. Arm C (bevacizumab and sorafenib tosylate) Bevacizumab Patients receive bevacizumab as in Arm A and sorafenib tosylate PO BID on days 1-5, 8-12, 15-19, and 22-26. Arm C (bevacizumab and sorafenib tosylate) Laboratory Biomarker Analysis Patients receive bevacizumab as in Arm A and sorafenib tosylate PO BID on days 1-5, 8-12, 15-19, and 22-26. Arm C (bevacizumab and sorafenib tosylate) Pharmacological Study Patients receive bevacizumab as in Arm A and sorafenib tosylate PO BID on days 1-5, 8-12, 15-19, and 22-26. Arm D (sorafenib tosylate and temsirolimus) Temsirolimus Patients receive sorafenib tosylate PO BID on days 1-28 and temsirolimus as in Arm B. Arm C (bevacizumab and sorafenib tosylate) Sorafenib Tosylate Patients receive bevacizumab as in Arm A and sorafenib tosylate PO BID on days 1-5, 8-12, 15-19, and 22-26. Arm D (sorafenib tosylate and temsirolimus) Sorafenib Tosylate Patients receive sorafenib tosylate PO BID on days 1-28 and temsirolimus as in Arm B.
- Primary Outcome Measures
Name Time Method Progression-free Survival (PFS) Assessed every 2 cycles for the first 12 cycles, then every 3 cycles until treatment discontinuation, then every 8 weeks until disease progression or up to 5 years Progression-free survival is defined as time from randomization to clinical evidence of disease progression or death from any cause without progression. Patients alive without progression were censored at the date of last disease assessment.
- Secondary Outcome Measures
Name Time Method Proportion of Patients With Stable Disease at 6 Months Assessed every 2 cycles for the first 12 cycles, then every 3 cycles until treatment discontinuation, then every 8 weeks until disease progression or up to 5 years Patients whose date of progression was after 6 months or who were disease-free at last follow-up beyond 6 months were considered to be stable at 6 months and all other patients were not.
Overall Survival Assessed every 2 cycles for the first 12 cycles, then every 3 cycles until treatment discontinuation, then every 8 weeks until disease progression or up to 5 years Overall survival was defined as the time from randomization to death. Patients alive at last contact were censored on the date of last contact.
Objective Response Rate Assessed every 2 cycles for the first 12 cycles, then every 3 cycles until treatment discontinuation, then every 8 weeks until disease progression or up to 5 years Response was assessed using Solid Tumor Response Criteria (RECIST). Patients with complete responses or partial responses are considered having an objective response.
Trial Locations
- Locations (557)
Riverside Methodist Hospital
🇺🇸Columbus, Ohio, United States
Grant Medical Center
🇺🇸Columbus, Ohio, United States
Jesse Brown Veterans Affairs Medical Center
🇺🇸Chicago, Illinois, United States
University of Illinois
🇺🇸Chicago, Illinois, United States
MetroHealth Medical Center
🇺🇸Cleveland, Ohio, United States
University of Washington Medical Center
🇺🇸Seattle, Washington, United States
Baylor Saint Luke's Medical Center
🇺🇸Houston, Texas, United States
Ben Taub General Hospital
🇺🇸Houston, Texas, United States
The Methodist Hospital System
🇺🇸Houston, Texas, United States
Michael E DeBakey VA Medical Center
🇺🇸Houston, Texas, United States
University Medical Center of Southern Nevada
🇺🇸Las Vegas, Nevada, United States
University of California San Diego
🇺🇸San Diego, California, United States
Veterans Administration-San Diego Medical Center
🇺🇸San Diego, California, United States
The Christ Hospital
🇺🇸Cincinnati, Ohio, United States
Virginia Piper Cancer Institute
🇺🇸Minneapolis, Minnesota, United States
California Pacific Medical Center-Pacific Campus
🇺🇸San Francisco, California, United States
Vanderbilt University/Ingram Cancer Center
🇺🇸Nashville, Tennessee, United States
Associates In Womens Health
🇺🇸Wichita, Kansas, United States
Cotton O'Neil Cancer Center / Stormont Vail Health
🇺🇸Topeka, Kansas, United States
Southwest Medical Center
🇺🇸Liberal, Kansas, United States
Wichita NCI Community Oncology Research Program
🇺🇸Wichita, Kansas, United States
Cancer Center of Kansas - Wellington
🇺🇸Wellington, Kansas, United States
Lawrence Memorial Hospital
🇺🇸Lawrence, Kansas, United States
Shawnee Mission Medical Center-KCCC
🇺🇸Shawnee Mission, Kansas, United States
University of Rochester
🇺🇸Rochester, New York, United States
Menorah Medical Center
🇺🇸Overland Park, Kansas, United States
Cancer Center of Kansas-Independence
🇺🇸Independence, Kansas, United States
University of Mississippi Medical Center
🇺🇸Jackson, Mississippi, United States
Cancer Center of Kansas - Winfield
🇺🇸Winfield, Kansas, United States
Cancer Center of Kansas - El Dorado
🇺🇸El Dorado, Kansas, United States
Cancer Center of Kansas - Salina
🇺🇸Salina, Kansas, United States
Saint Francis Hospital and Medical Center - Topeka
🇺🇸Topeka, Kansas, United States
Graham Hospital Association
🇺🇸Canton, Illinois, United States
Cancer Center of Kansas - Pratt
🇺🇸Pratt, Kansas, United States
Cancer Center of Kansas - Fort Scott
🇺🇸Fort Scott, Kansas, United States
Cancer Center of Kansas - Parsons
🇺🇸Parsons, Kansas, United States
Hospital District Sixth of Harper County
🇺🇸Anthony, Kansas, United States
Community Howard Regional Health
🇺🇸Kokomo, Indiana, United States
Sidney and Lois Eskenazi Hospital
🇺🇸Indianapolis, Indiana, United States
Elkhart General Hospital
🇺🇸Elkhart, Indiana, United States
Oncology Associates at Mercy Medical Center
🇺🇸Cedar Rapids, Iowa, United States
Genesis Medical Center - East Campus
🇺🇸Davenport, Iowa, United States
Fort Wayne Medical Oncology and Hematology Inc-Parkview
🇺🇸Fort Wayne, Indiana, United States
Northern Indiana Cancer Research Consortium
🇺🇸South Bend, Indiana, United States
IU Health La Porte Hospital
🇺🇸La Porte, Indiana, United States
Indiana University/Melvin and Bren Simon Cancer Center
🇺🇸Indianapolis, Indiana, United States
Mercy Hospital
🇺🇸Scranton, Pennsylvania, United States
Cancer Center of Kansas - Chanute
🇺🇸Chanute, Kansas, United States
South Bend Clinic
🇺🇸South Bend, Indiana, United States
Richard L. Roudebush Veterans Affairs Medical Center
🇺🇸Indianapolis, Indiana, United States
Michiana Hematology Oncology PC-Elkhart
🇺🇸Elkhart, Indiana, United States
McFarland Clinic PC - Ames
🇺🇸Ames, Iowa, United States
Constantinou, Costas L MD (UIA Investigator)
🇺🇸Bettendorf, Iowa, United States
Mercy Hospital Springfield
🇺🇸Springfield, Missouri, United States
Northern Rockies Radiation Oncology Center
🇺🇸Billings, Montana, United States
Bozeman Deaconess Hospital
🇺🇸Bozeman, Montana, United States
Heartland Regional Medical Center
🇺🇸Saint Joseph, Missouri, United States
Saint Vincent Healthcare
🇺🇸Billings, Montana, United States
Saint Luke's East - Lee's Summit
🇺🇸Lee's Summit, Missouri, United States
Center for Cancer Care and Research
🇺🇸Saint Louis, Missouri, United States
Billings Clinic Cancer Center
🇺🇸Billings, Montana, United States
Big Sky Oncology
🇺🇸Great Falls, Montana, United States
CHI Health Saint Francis
🇺🇸Grand Island, Nebraska, United States
Great Falls Clinic
🇺🇸Great Falls, Montana, United States
Atrium Medical Center-Middletown Regional Hospital
🇺🇸Franklin, Ohio, United States
Mercy Cancer Center-Elyria
🇺🇸Elyria, Ohio, United States
Wayne Hospital
🇺🇸Greenville, Ohio, United States
Blanchard Valley Hospital
🇺🇸Findlay, Ohio, United States
Grandview Hospital
🇺🇸Dayton, Ohio, United States
Miami Valley Hospital
🇺🇸Dayton, Ohio, United States
Good Samaritan Hospital - Dayton
🇺🇸Dayton, Ohio, United States
Saint Luke's Hospital
🇺🇸Maumee, Ohio, United States
University of Toledo
🇺🇸Toledo, Ohio, United States
Hematology and Oncology Associates of North East Pennsylvania
🇺🇸Scranton, Pennsylvania, United States
Grady Memorial Hospital
🇺🇸Delaware, Ohio, United States
Veteran Affairs Medical Center
🇺🇸Dayton, Ohio, United States
Fremont Memorial Hospital
🇺🇸Fremont, Ohio, United States
Thomas Jefferson University Hospital
🇺🇸Philadelphia, Pennsylvania, United States
Mount Carmel Health Center West
🇺🇸Columbus, Ohio, United States
Dayton NCI Community Oncology Research Program
🇺🇸Dayton, Ohio, United States
Fairfield Medical Center
🇺🇸Lancaster, Ohio, United States
Toledo Clinic Cancer Centers-Oregon
🇺🇸Oregon, Ohio, United States
Geisinger Medical Center-Cancer Center Hazleton
🇺🇸Hazleton, Pennsylvania, United States
Avera McKennan Hospital and University Health Center
🇺🇸Sioux Falls, South Dakota, United States
Sanford USD Medical Center - Sioux Falls
🇺🇸Sioux Falls, South Dakota, United States
Springfield Regional Medical Center
🇺🇸Springfield, Ohio, United States
Hematology Oncology Center Incorporated
🇺🇸Elyria, Ohio, United States
Marietta Memorial Hospital
🇺🇸Marietta, Ohio, United States
Bryn Mawr Hospital
🇺🇸Bryn Mawr, Pennsylvania, United States
Vanderbilt-Ingram Cancer Center Cool Springs
🇺🇸Franklin, Tennessee, United States
The Toledo Hospital/Toledo Children's Hospital
🇺🇸Toledo, Ohio, United States
Bay Area Hospital
🇺🇸Coos Bay, Oregon, United States
Fisher-Titus Medical Center
🇺🇸Norwalk, Ohio, United States
Natalie Warren Bryant Cancer Center at Saint Francis
🇺🇸Tulsa, Oklahoma, United States
Lehigh Valley Hospital-Cedar Crest
🇺🇸Allentown, Pennsylvania, United States
AnMed Health Hospital
🇺🇸Anderson, South Carolina, United States
Licking Memorial Hospital
🇺🇸Newark, Ohio, United States
Saint Charles Hospital
🇺🇸Oregon, Ohio, United States
Geisinger Medical Center
🇺🇸Danville, Pennsylvania, United States
Kadlec Clinic Hematology and Oncology
🇺🇸Kennewick, Washington, United States
East Tennessee Baptist Hospital-Mercy Health Partners
🇺🇸Knoxville, Tennessee, United States
Spartanburg Medical Center
🇺🇸Spartanburg, South Carolina, United States
Sanford Cancer Center Oncology Clinic
🇺🇸Sioux Falls, South Dakota, United States
Fredericksburg Oncology Inc
🇺🇸Fredericksburg, Virginia, United States
Avera Cancer Institute
🇺🇸Sioux Falls, South Dakota, United States
Bay Area Medical Center
🇺🇸Marinette, Wisconsin, United States
Danville Regional Medical Center
🇺🇸Danville, Virginia, United States
Harrison HealthPartners Hematology and Oncology-Poulsbo
🇺🇸Poulsbo, Washington, United States
Green Bay Oncology at Saint Vincent Hospital
🇺🇸Green Bay, Wisconsin, United States
HSHS Sacred Heart Hospital
🇺🇸Eau Claire, Wisconsin, United States
Saint Vincent Hospital Cancer Center at Saint Mary's
🇺🇸Green Bay, Wisconsin, United States
Thompson Cancer Survival Center
🇺🇸Knoxville, Tennessee, United States
University of Tennessee - Knoxville
🇺🇸Knoxville, Tennessee, United States
PeaceHealth Saint Joseph Medical Center
🇺🇸Bellingham, Washington, United States
The Center for Cancer and Blood Disorders-Mineral Wells
🇺🇸Mineral Wells, Texas, United States
Kaiser Permanente Washington
🇺🇸Seattle, Washington, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
🇺🇸Houston, Texas, United States
Fox Valley Hematology and Oncology SC-Appleton
🇺🇸Appleton, Wisconsin, United States
Marshfield Clinic Cancer Center at Sacred Heart
🇺🇸Eau Claire, Wisconsin, United States
Sovah Health Martinsville
🇺🇸Martinsville, Virginia, United States
Holy Family Memorial Hospital
🇺🇸Manitowoc, Wisconsin, United States
The Center for Cancer and Blood Disorders-Weatherford
🇺🇸Weatherford, Texas, United States
Ascension Saint Mary's Hospital
🇺🇸Rhinelander, Wisconsin, United States
Skagit Valley Hospital
🇺🇸Mount Vernon, Washington, United States
Rocky Mountain Oncology
🇺🇸Casper, Wyoming, United States
Marshfield Clinic-Chippewa Center
🇺🇸Chippewa Falls, Wisconsin, United States
UW Cancer Center Johnson Creek
🇺🇸Johnson Creek, Wisconsin, United States
Welch Cancer Center
🇺🇸Sheridan, Wyoming, United States
Harrison HealthPartners Hematology and Oncology-Bremerton
🇺🇸Bremerton, Washington, United States
Marshfield Clinic-Minocqua Center
🇺🇸Minocqua, Wisconsin, United States
West Virginia University Charleston Division
🇺🇸Charleston, West Virginia, United States
Marshfield Medical Center
🇺🇸Marshfield, Wisconsin, United States
Diagnostic and Treatment Center
🇺🇸Weston, Wisconsin, United States
Marshfield Clinic-Rice Lake Center
🇺🇸Rice Lake, Wisconsin, United States
Marshfield Clinic - Wisconsin Rapids Center
🇺🇸Wisconsin Rapids, Wisconsin, United States
University of Alabama at Birmingham Cancer Center
🇺🇸Birmingham, Alabama, United States
Rose Medical Center
🇺🇸Denver, Colorado, United States
Porter Adventist Hospital
🇺🇸Denver, Colorado, United States
University of Colorado
🇺🇸Denver, Colorado, United States
Presbyterian - Saint Lukes Medical Center - Health One
🇺🇸Denver, Colorado, United States
SCL Health Saint Joseph Hospital
🇺🇸Denver, Colorado, United States
Colorado Cancer Research Program NCORP
🇺🇸Denver, Colorado, United States
Kaiser Permanente Northwest
🇺🇸Portland, Oregon, United States
Liberty Radiation Oncology Center
🇺🇸Liberty, Missouri, United States
Saint Louis-Cape Girardeau CCOP
🇺🇸Saint Louis, Missouri, United States
Saint Joseph Oncology Inc
🇺🇸Saint Joseph, Missouri, United States
Saint Louis University Hospital
🇺🇸Saint Louis, Missouri, United States
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States
University of Oklahoma Health Sciences Center
🇺🇸Oklahoma City, Oklahoma, United States
Ottawa Regional Hospital and Healthcare Center
🇺🇸Ottawa, Illinois, United States
Memorial Hospital of South Bend
🇺🇸South Bend, Indiana, United States
Horizon Oncology Research LLC
🇺🇸Lafayette, Indiana, United States
Franciscan Saint Anthony Health-Michigan City
🇺🇸Michigan City, Indiana, United States
Michiana Hematology Oncology PC-Westville
🇺🇸Westville, Indiana, United States
Scranton Hematology Oncology
🇺🇸Scranton, Pennsylvania, United States
University of Pennsylvania/Abramson Cancer Center
🇺🇸Philadelphia, Pennsylvania, United States
Riddle Memorial Hospital
🇺🇸Media, Pennsylvania, United States
Paoli Memorial Hospital
🇺🇸Paoli, Pennsylvania, United States
Einstein Medical Center Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
Geisinger Wyoming Valley/Henry Cancer Center
🇺🇸Wilkes-Barre, Pennsylvania, United States
University of Iowa/Holden Comprehensive Cancer Center
🇺🇸Iowa City, Iowa, United States
Genesis Medical Center - West Campus
🇺🇸Davenport, Iowa, United States
Mercy Medical Center - North Iowa
🇺🇸Mason City, Iowa, United States
Lankenau Medical Center
🇺🇸Wynnewood, Pennsylvania, United States
Marshfield Clinic-Wausau Center
🇺🇸Wausau, Wisconsin, United States
Marshfield Clinic - Weston Center
🇺🇸Weston, Wisconsin, United States
Aspirus UW Cancer Center
🇺🇸Wisconsin Rapids, Wisconsin, United States
Gundersen Lutheran Medical Center
🇺🇸La Crosse, Wisconsin, United States
Wenatchee Valley Hospital and Clinics
🇺🇸Wenatchee, Washington, United States
Saint Luke's University Hospital-Bethlehem Campus
🇺🇸Bethlehem, Pennsylvania, United States
Central PA Hematology-Medical Oncology Associates PC
🇺🇸Lemoyne, Pennsylvania, United States
Southeast Clinical Oncology Research (SCOR) Consortium NCORP
🇺🇸Winston-Salem, North Carolina, United States
Wake Forest University Health Sciences
🇺🇸Winston-Salem, North Carolina, United States
Research Medical Center
🇺🇸Kansas City, Missouri, United States
Providence Hospital
🇺🇸Mobile, Alabama, United States
Mayo Clinic in Arizona
🇺🇸Scottsdale, Arizona, United States
Mercy Hospital Fort Smith
🇺🇸Fort Smith, Arkansas, United States
NEA Baptist Memorial Hospital
🇺🇸Jonesboro, Arkansas, United States
University of Arkansas for Medical Sciences
🇺🇸Little Rock, Arkansas, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center
🇺🇸Burbank, California, United States
Alta Bates Summit Medical Center-Herrick Campus
🇺🇸Berkeley, California, United States
Mills-Peninsula Medical Center
🇺🇸Burlingame, California, United States
Valley Medical Oncology Consultants-Fremont
🇺🇸Fremont, California, United States
Eden Hospital Medical Center
🇺🇸Castro Valley, California, United States
USC / Norris Comprehensive Cancer Center
🇺🇸Los Angeles, California, United States
Marin Cancer Care Inc
🇺🇸Greenbrae, California, United States
Contra Costa Regional Medical Center
🇺🇸Martinez, California, United States
UC San Diego Moores Cancer Center
🇺🇸La Jolla, California, United States
Marin General Hospital
🇺🇸Greenbrae, California, United States
Fremont - Rideout Cancer Center
🇺🇸Marysville, California, United States
El Camino Hospital
🇺🇸Mountain View, California, United States
Palo Alto Medical Foundation-Camino Division
🇺🇸Mountain View, California, United States
Highland General Hospital
🇺🇸Oakland, California, United States
Alta Bates Summit Medical Center - Summit Campus
🇺🇸Oakland, California, United States
Bay Area Tumor Institute
🇺🇸Oakland, California, United States
Hematology and Oncology Associates-Oakland
🇺🇸Oakland, California, United States
Saint Joseph Hospital - Orange
🇺🇸Orange, California, United States
Valley Care Health System - Pleasanton
🇺🇸Pleasanton, California, United States
Valley Medical Oncology Consultants
🇺🇸Pleasanton, California, United States
Palo Alto Medical Foundation Health Care
🇺🇸Palo Alto, California, United States
Tom K Lee Inc
🇺🇸Oakland, California, United States
Gene Upshaw Memorial Tahoe Forest Cancer Center
🇺🇸Truckee, California, United States
Penrose-Saint Francis Healthcare
🇺🇸Colorado Springs, Colorado, United States
Boulder Community Hospital
🇺🇸Boulder, Colorado, United States
UCHealth Memorial Hospital Central
🇺🇸Colorado Springs, Colorado, United States
The Shaw Regional Cancer Center
🇺🇸Edwards, Colorado, United States
Swedish Medical Center
🇺🇸Englewood, Colorado, United States
Poudre Valley Hospital
🇺🇸Fort Collins, Colorado, United States
Valley View Hospital Cancer Center
🇺🇸Glenwood Springs, Colorado, United States
North Colorado Medical Center
🇺🇸Greeley, Colorado, United States
Saint Mary's Hospital and Regional Medical Center
🇺🇸Grand Junction, Colorado, United States
Saint Anthony Hospital
🇺🇸Lakewood, Colorado, United States
Sky Ridge Medical Center
🇺🇸Lone Tree, Colorado, United States
McKee Medical Center
🇺🇸Loveland, Colorado, United States
Longmont United Hospital
🇺🇸Longmont, Colorado, United States
North Suburban Medical Center
🇺🇸Thornton, Colorado, United States
Saint Mary Corwin Medical Center
🇺🇸Pueblo, Colorado, United States
Montrose Memorial Hospital
🇺🇸Montrose, Colorado, United States
Hartford Hospital
🇺🇸Hartford, Connecticut, United States
SCL Health Lutheran Medical Center
🇺🇸Wheat Ridge, Colorado, United States
Beebe Medical Center
🇺🇸Lewes, Delaware, United States
Christiana Care Health System-Christiana Hospital
🇺🇸Newark, Delaware, United States
Mayo Clinic in Florida
🇺🇸Jacksonville, Florida, United States
John B Amos Cancer Center
🇺🇸Columbus, Georgia, United States
Boca Raton Regional Hospital
🇺🇸Boca Raton, Florida, United States
UF Cancer Center at Orlando Health
🇺🇸Orlando, Florida, United States
Northeast Georgia Medical Center-Gainesville
🇺🇸Gainesville, Georgia, United States
Medical Center of Central Georgia
🇺🇸Macon, Georgia, United States
Kootenai Cancer Center
🇺🇸Post Falls, Idaho, United States
Saint Anthony's Health
🇺🇸Alton, Illinois, United States
Rush - Copley Medical Center
🇺🇸Aurora, Illinois, United States
MacNeal Hospital and Cancer Center
🇺🇸Berwyn, Illinois, United States
Saint Joseph Medical Center
🇺🇸Bloomington, Illinois, United States
Illinois CancerCare-Bloomington
🇺🇸Bloomington, Illinois, United States
Illinois CancerCare-Canton
🇺🇸Canton, Illinois, United States
Illinois CancerCare-Carthage
🇺🇸Carthage, Illinois, United States
Memorial Hospital
🇺🇸Carthage, Illinois, United States
Hematology and Oncology Associates
🇺🇸Chicago, Illinois, United States
Northwestern University
🇺🇸Chicago, Illinois, United States
University of Chicago Comprehensive Cancer Center
🇺🇸Chicago, Illinois, United States
Presence Resurrection Medical Center
🇺🇸Chicago, Illinois, United States
Decatur Memorial Hospital
🇺🇸Decatur, Illinois, United States
Heartland Cancer Research NCORP
🇺🇸Decatur, Illinois, United States
Eureka Hospital
🇺🇸Eureka, Illinois, United States
AMITA Health Alexian Brothers Medical Center
🇺🇸Elk Grove Village, Illinois, United States
Advocate Sherman Hospital
🇺🇸Elgin, Illinois, United States
Illinois CancerCare-Eureka
🇺🇸Eureka, Illinois, United States
NorthShore University HealthSystem-Evanston Hospital
🇺🇸Evanston, Illinois, United States
Illinois CancerCare-Cottage
🇺🇸Galesburg, Illinois, United States
Illinois CancerCare-Galesburg
🇺🇸Galesburg, Illinois, United States
Illinois CancerCare-Havana
🇺🇸Havana, Illinois, United States
Midwest Center for Hematology Oncology
🇺🇸Joliet, Illinois, United States
Galesburg Cottage Hospital
🇺🇸Galesburg, Illinois, United States
Hopedale Medical Complex - Hospital
🇺🇸Hopedale, Illinois, United States
Ingalls Memorial Hospital
🇺🇸Harvey, Illinois, United States
Joliet Oncology-Hematology Associates Limited
🇺🇸Joliet, Illinois, United States
Illinois CancerCare-Kewanee Clinic
🇺🇸Kewanee, Illinois, United States
Kewanee Hospital
🇺🇸Kewanee, Illinois, United States
Illinois CancerCare-Macomb
🇺🇸Macomb, Illinois, United States
AMITA Health Adventist Medical Center
🇺🇸La Grange, Illinois, United States
NorthShore Hematology Oncology-Libertyville
🇺🇸Libertyville, Illinois, United States
Porubcin, Michael MD (UIA Investigator)
🇺🇸Moline, Illinois, United States
Sharis, Christine M MD (UIA Investigator)
🇺🇸Moline, Illinois, United States
Garneau, Stewart C MD (UIA Investigator)
🇺🇸Moline, Illinois, United States
Mcdonough District Hospital
🇺🇸Macomb, Illinois, United States
Stoffel, Thomas J MD (UIA Investigator)
🇺🇸Moline, Illinois, United States
Spector, David MD (UIA Investigator)
🇺🇸Moline, Illinois, United States
Trinity Medical Center
🇺🇸Moline, Illinois, United States
Holy Family Medical Center
🇺🇸Monmouth, Illinois, United States
Illinois CancerCare-Monmouth
🇺🇸Monmouth, Illinois, United States
Good Samaritan Regional Health Center
🇺🇸Mount Vernon, Illinois, United States
DuPage Medical Group-Ogden
🇺🇸Naperville, Illinois, United States
AMG Oncology - Naperville
🇺🇸Naperville, Illinois, United States
Illinois Cancer Specialists-Niles
🇺🇸Niles, Illinois, United States
Bromenn Regional Medical Center
🇺🇸Normal, Illinois, United States
Community Cancer Center Foundation
🇺🇸Normal, Illinois, United States
Illinois CancerCare-Community Cancer Center
🇺🇸Normal, Illinois, United States
Illinois CancerCare-Pekin
🇺🇸Pekin, Illinois, United States
Illinois CancerCare-Ottawa Clinic
🇺🇸Ottawa, Illinois, United States
Pekin Hospital
🇺🇸Pekin, Illinois, United States
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
🇺🇸Pekin, Illinois, United States
Proctor Hospital
🇺🇸Peoria, Illinois, United States
Illinois CancerCare-Peoria
🇺🇸Peoria, Illinois, United States
Methodist Medical Center of Illinois
🇺🇸Peoria, Illinois, United States
Illinois CancerCare-Peru
🇺🇸Peru, Illinois, United States
Illinois CancerCare-Princeton
🇺🇸Princeton, Illinois, United States
OSF Saint Francis Medical Center
🇺🇸Peoria, Illinois, United States
Illinois Valley Hospital
🇺🇸Peru, Illinois, United States
Perry Memorial Hospital
🇺🇸Princeton, Illinois, United States
Hematology Oncology Associates of Illinois - Skokie
🇺🇸Skokie, Illinois, United States
Swedish American Hospital
🇺🇸Rockford, Illinois, United States
SwedishAmerican Regional Cancer Center/ACT
🇺🇸Rockford, Illinois, United States
Saint Margaret's Hospital
🇺🇸Spring Valley, Illinois, United States
Memorial Medical Center
🇺🇸Springfield, Illinois, United States
Carle Cancer Center
🇺🇸Urbana, Illinois, United States
Franciscan Saint Francis Health-Beech Grove
🇺🇸Beech Grove, Indiana, United States
Elkhart Clinic
🇺🇸Elkhart, Indiana, United States
Saint Joseph Regional Medical Center-Mishawaka
🇺🇸Mishawaka, Indiana, United States
Michiana Hematology Oncology PC-Plymouth
🇺🇸Plymouth, Indiana, United States
Reid Health
🇺🇸Richmond, Indiana, United States
Michiana Hematology Oncology PC-South Bend
🇺🇸South Bend, Indiana, United States
University of Iowa Healthcare Cancer Services Quad Cities
🇺🇸Bettendorf, Iowa, United States
Ottumwa Regional Health Center
🇺🇸Ottumwa, Iowa, United States
Saint Luke's Regional Medical Center
🇺🇸Sioux City, Iowa, United States
Siouxland Regional Cancer Center
🇺🇸Sioux City, Iowa, United States
Mercy Medical Center-Sioux City
🇺🇸Sioux City, Iowa, United States
Cancer Center of Kansas - Dodge City
🇺🇸Dodge City, Kansas, United States
Cancer Center of Kansas-Kingman
🇺🇸Kingman, Kansas, United States
Cancer Center of Kansas - Newton
🇺🇸Newton, Kansas, United States
Saint Luke's South Hospital
🇺🇸Overland Park, Kansas, United States
Radiation Oncology Practice Corporation Southwest
🇺🇸Overland Park, Kansas, United States
Cancer Center of Kansas-Wichita Medical Arts Tower
🇺🇸Wichita, Kansas, United States
Cancer Center of Kansas - Wichita
🇺🇸Wichita, Kansas, United States
Via Christi Regional Medical Center
🇺🇸Wichita, Kansas, United States
Mary Bird Perkins Cancer Center
🇺🇸Baton Rouge, Louisiana, United States
Baton Rouge General Medical Center
🇺🇸Baton Rouge, Louisiana, United States
Ochsner Health Center-Summa
🇺🇸Baton Rouge, Louisiana, United States
Eastern Maine Medical Center
🇺🇸Bangor, Maine, United States
Greater Baltimore Medical Center
🇺🇸Baltimore, Maryland, United States
Saint Mary's Regional Medical Center
🇺🇸Lewiston, Maine, United States
Union Hospital of Cecil County
🇺🇸Elkton, Maryland, United States
Sinai Hospital of Baltimore
🇺🇸Baltimore, Maryland, United States
Frederick Memorial Hospital
🇺🇸Frederick, Maryland, United States
Beth Israel Deaconess Medical Center
🇺🇸Boston, Massachusetts, United States
Bixby Medical Center
🇺🇸Adrian, Michigan, United States
Hickman Cancer Center
🇺🇸Adrian, Michigan, United States
Ascension Saint John Hospital
🇺🇸Detroit, Michigan, United States
Beaumont Hospital-Dearborn
🇺🇸Dearborn, Michigan, United States
Bronson Battle Creek
🇺🇸Battle Creek, Michigan, United States
Spectrum Health Big Rapids Hospital
🇺🇸Big Rapids, Michigan, United States
Green Bay Oncology - Escanaba
🇺🇸Escanaba, Michigan, United States
Genesys Hurley Cancer Institute
🇺🇸Flint, Michigan, United States
Hurley Medical Center
🇺🇸Flint, Michigan, United States
Mercy Health Saint Mary's
🇺🇸Grand Rapids, Michigan, United States
Green Bay Oncology - Iron Mountain
🇺🇸Iron Mountain, Michigan, United States
Cancer Research Consortium of West Michigan NCORP
🇺🇸Grand Rapids, Michigan, United States
Genesys Regional Medical Center-West Flint Campus
🇺🇸Flint, Michigan, United States
Spectrum Health at Butterworth Campus
🇺🇸Grand Rapids, Michigan, United States
Bronson Methodist Hospital
🇺🇸Kalamazoo, Michigan, United States
Allegiance Health
🇺🇸Jackson, Michigan, United States
West Michigan Cancer Center
🇺🇸Kalamazoo, Michigan, United States
Borgess Medical Center
🇺🇸Kalamazoo, Michigan, United States
Sparrow Hospital
🇺🇸Lansing, Michigan, United States
Saint Mary Mercy Hospital
🇺🇸Livonia, Michigan, United States
Mercy Memorial Hospital
🇺🇸Monroe, Michigan, United States
Mercy Health Partners-Hackley Campus
🇺🇸Muskegon, Michigan, United States
Toledo Clinic Cancer Centers-Monroe
🇺🇸Monroe, Michigan, United States
Mercy Health Mercy Campus
🇺🇸Muskegon, Michigan, United States
Lakeland Hospital Niles
🇺🇸Niles, Michigan, United States
Lake Huron Medical Center
🇺🇸Port Huron, Michigan, United States
Lakeland Medical Center Saint Joseph
🇺🇸Saint Joseph, Michigan, United States
Marie Yeager Cancer Center
🇺🇸Saint Joseph, Michigan, United States
Oncology Care Associates PLLC
🇺🇸Saint Joseph, Michigan, United States
Providence Hospital-Southfield Cancer Center
🇺🇸Southfield, Michigan, United States
Munson Medical Center
🇺🇸Traverse City, Michigan, United States
Metro Health Hospital
🇺🇸Wyoming, Michigan, United States
Medini, Eitan MD (UIA Investigator)
🇺🇸Alexandria, Minnesota, United States
Fairview Ridges Hospital
🇺🇸Burnsville, Minnesota, United States
Fairview-Southdale Hospital
🇺🇸Edina, Minnesota, United States
Essentia Health Cancer Center
🇺🇸Duluth, Minnesota, United States
Essentia Health Saint Mary's Medical Center
🇺🇸Duluth, Minnesota, United States
Etzell, Paul S MD (UIA Investigator)
🇺🇸Fergus Falls, Minnesota, United States
Swenson, Wade II, MD (UIA Investigator)
🇺🇸Fergus Falls, Minnesota, United States
Unity Hospital
🇺🇸Fridley, Minnesota, United States
Meeker County Memorial Hospital
🇺🇸Litchfield, Minnesota, United States
Hutchinson Area Health Care
🇺🇸Hutchinson, Minnesota, United States
Minnesota Oncology Hematology PA-Maplewood
🇺🇸Maplewood, Minnesota, United States
Saint John's Hospital - Healtheast
🇺🇸Maplewood, Minnesota, United States
Abbott-Northwestern Hospital
🇺🇸Minneapolis, Minnesota, United States
Hennepin County Medical Center
🇺🇸Minneapolis, Minnesota, United States
Coborn Cancer Center at Saint Cloud Hospital
🇺🇸Saint Cloud, Minnesota, United States
Saint Cloud Hospital
🇺🇸Saint Cloud, Minnesota, United States
Metro Minnesota Community Oncology Research Consortium
🇺🇸Saint Louis Park, Minnesota, United States
Park Nicollet Clinic - Saint Louis Park
🇺🇸Saint Louis Park, Minnesota, United States
Regions Hospital
🇺🇸Saint Paul, Minnesota, United States
United Hospital
🇺🇸Saint Paul, Minnesota, United States
Saint Joseph's Hospital - Healtheast
🇺🇸Saint Paul, Minnesota, United States
Saint Francis Regional Medical Center
🇺🇸Shakopee, Minnesota, United States
Ridgeview Medical Center
🇺🇸Waconia, Minnesota, United States
Rice Memorial Hospital
🇺🇸Willmar, Minnesota, United States
Minnesota Oncology Hematology PA-Woodbury
🇺🇸Woodbury, Minnesota, United States
Woodwinds Health Campus
🇺🇸Woodbury, Minnesota, United States
Singing River Hospital
🇺🇸Pascagoula, Mississippi, United States
Centerpoint Medical Center LLC
🇺🇸Independence, Missouri, United States
Mercy Hospital Joplin
🇺🇸Joplin, Missouri, United States
Saint Joseph Health Center
🇺🇸Kansas City, Missouri, United States
Saint Louis Cancer and Breast Institute-South City
🇺🇸Saint Louis, Missouri, United States
CoxHealth South Hospital
🇺🇸Springfield, Missouri, United States
Saint James Community Hospital and Cancer Treatment Center
🇺🇸Butte, Montana, United States
Saint Peter's Community Hospital
🇺🇸Helena, Montana, United States
Saint Patrick Hospital - Community Hospital
🇺🇸Missoula, Montana, United States
Glacier Oncology PLLC
🇺🇸Kalispell, Montana, United States
Community Medical Hospital
🇺🇸Missoula, Montana, United States
Guardian Oncology and Center for Wellness
🇺🇸Missoula, Montana, United States
Great Plains Health Callahan Cancer Center
🇺🇸North Platte, Nebraska, United States
CHI Health Good Samaritan
🇺🇸Kearney, Nebraska, United States
Nevada Cancer Research Foundation CCOP
🇺🇸Las Vegas, Nevada, United States
Cooper Hospital University Medical Center
🇺🇸Camden, New Jersey, United States
Portsmouth Regional Hospital
🇺🇸Portsmouth, New Hampshire, United States
Morristown Medical Center
🇺🇸Morristown, New Jersey, United States
Veterans Adminstration New Jersey Health Care System
🇺🇸East Orange, New Jersey, United States
Virtua Memorial
🇺🇸Mount Holly, New Jersey, United States
Rutgers New Jersey Medical School
🇺🇸Newark, New Jersey, United States
Overlook Hospital
🇺🇸Summit, New Jersey, United States
Kings County Hospital
🇺🇸Brooklyn, New York, United States
Glens Falls Hospital
🇺🇸Glens Falls, New York, United States
Mary Imogene Bassett Hospital
🇺🇸Cooperstown, New York, United States
Hematology Oncology Associates of Central New York-East Syracuse
🇺🇸East Syracuse, New York, United States
Northwell Health NCORP
🇺🇸Lake Success, New York, United States
Orange Regional Medical Center
🇺🇸Middletown, New York, United States
Long Island Jewish Medical Center
🇺🇸New Hyde Park, New York, United States
Columbia University/Herbert Irving Cancer Center
🇺🇸New York, New York, United States
Mission Hospital Inc-Memorial Campus
🇺🇸Asheville, North Carolina, United States
Cone Health Cancer Center at Alamance Regional
🇺🇸Burlington, North Carolina, United States
Novant Health Presbyterian Medical Center
🇺🇸Charlotte, North Carolina, United States
Southeastern Medical Oncology Center-Goldsboro
🇺🇸Goldsboro, North Carolina, United States
Wayne Memorial Hospital
🇺🇸Goldsboro, North Carolina, United States
Margaret R Pardee Memorial Hospital
🇺🇸Hendersonville, North Carolina, United States
Vidant Oncology-Kinston
🇺🇸Kinston, North Carolina, United States
Rutherford Hospital
🇺🇸Rutherfordton, North Carolina, United States
Saint Alexius Medical Center
🇺🇸Bismarck, North Dakota, United States
Mid Dakota Clinic
🇺🇸Bismarck, North Dakota, United States
Sanford Bismarck Medical Center
🇺🇸Bismarck, North Dakota, United States
Mary Rutan Hospital
🇺🇸Bellefontaine, Ohio, United States
Mercy Medical Center
🇺🇸Canton, Ohio, United States
Toledo Clinic Cancer Centers-Bowling Green
🇺🇸Bowling Green, Ohio, United States
Adena Regional Medical Center
🇺🇸Chillicothe, Ohio, United States
Columbus NCI Community Oncology Research Program
🇺🇸Columbus, Ohio, United States
North Coast Cancer Care-Clyde
🇺🇸Clyde, Ohio, United States
Doctors Hospital
🇺🇸Columbus, Ohio, United States
Saint Rita's Medical Center
🇺🇸Lima, Ohio, United States
Kettering Medical Center
🇺🇸Kettering, Ohio, United States
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
🇺🇸Maumee, Ohio, United States
Knox Community Hospital
🇺🇸Mount Vernon, Ohio, United States
Firelands Regional Medical Center
🇺🇸Sandusky, Ohio, United States
North Coast Cancer Care
🇺🇸Sandusky, Ohio, United States
Mercy Hospital of Tiffin
🇺🇸Tiffin, Ohio, United States
ProMedica Flower Hospital
🇺🇸Sylvania, Ohio, United States
Saint Vincent Mercy Medical Center
🇺🇸Toledo, Ohio, United States
Toledo Community Hospital Oncology Program CCOP
🇺🇸Toledo, Ohio, United States
Mercy Saint Anne Hospital
🇺🇸Toledo, Ohio, United States
Upper Valley Medical Center
🇺🇸Troy, Ohio, United States
Toledo Clinic Cancer Centers-Toledo
🇺🇸Toledo, Ohio, United States
Fulton County Health Center
🇺🇸Wauseon, Ohio, United States
Clinton Memorial Hospital
🇺🇸Wilmington, Ohio, United States
Saint Ann's Hospital
🇺🇸Westerville, Ohio, United States
Greene Memorial Hospital
🇺🇸Xenia, Ohio, United States
Reading Hospital
🇺🇸West Reading, Pennsylvania, United States
Memorial Hospital of Rhode Island
🇺🇸Pawtucket, Rhode Island, United States
Geisinger South Wilkes-Barre
🇺🇸Wilkes-Barre, Pennsylvania, United States
Medical X-Ray Center
🇺🇸Sioux Falls, South Dakota, United States
Jackson-Madison County General Hospital
🇺🇸Jackson, Tennessee, United States
Tennessee Cancer Specialists-Dowell Springs
🇺🇸Knoxville, Tennessee, United States
University of Tennessee Health Science Center
🇺🇸Memphis, Tennessee, United States
The Don and Sybil Harrington Cancer Center
🇺🇸Amarillo, Texas, United States
Texas Oncology-Cedar Park
🇺🇸Cedar Park, Texas, United States
The Center for Cancer and Blood Disorders-Burleson
🇺🇸Burleson, Texas, United States
The Center for Cancer and Blood Disorders-Cleburne
🇺🇸Cleburne, Texas, United States
Texas Oncology-Seton Williamson
🇺🇸Round Rock, Texas, United States
Minor and James Medical PLLC
🇺🇸Seattle, Washington, United States
Swedish Medical Center-First Hill
🇺🇸Seattle, Washington, United States
Cancer Care Northwest - Spokane South
🇺🇸Spokane, Washington, United States
Evergreen Hematology and Oncology PS
🇺🇸Spokane, Washington, United States
Rockwood Clinic
🇺🇸Spokane, Washington, United States
Green Bay Oncology Limited at Saint Mary's Hospital
🇺🇸Green Bay, Wisconsin, United States
Saint Vincent Hospital Cancer Center Green Bay
🇺🇸Green Bay, Wisconsin, United States
Marshfield Clinic
🇺🇸Marshfield, Wisconsin, United States
Green Bay Oncology - Oconto Falls
🇺🇸Oconto Falls, Wisconsin, United States
Green Bay Oncology - Sturgeon Bay
🇺🇸Sturgeon Bay, Wisconsin, United States
Saint Michael's Hospital
🇺🇸Stevens Point, Wisconsin, United States
Instituto Nacional de Enfermedades Neoplasicas
🇵🇪Lima, Peru
University of California Davis Comprehensive Cancer Center
🇺🇸Sacramento, California, United States
Froedtert and the Medical College of Wisconsin
🇺🇸Milwaukee, Wisconsin, United States
The Medical Center of Aurora
🇺🇸Aurora, Colorado, United States
University of Colorado Hospital
🇺🇸Aurora, Colorado, United States
Michigan Cancer Research Consortium NCORP
🇺🇸Ann Arbor, Michigan, United States
Saint Joseph Mercy Hospital
🇺🇸Ann Arbor, Michigan, United States
Mayo Clinic
🇺🇸Rochester, Minnesota, United States
Sutter Cancer Research Consortium
🇺🇸Novato, California, United States
East Bay Radiation Oncology Center
🇺🇸Castro Valley, California, United States
Bay Area Breast Surgeons Inc
🇺🇸Emeryville, California, United States
Doctors Medical Center- JC Robinson Regional Cancer Center
🇺🇸San Pablo, California, United States
The University of Arizona Medical Center-University Campus
🇺🇸Tucson, Arizona, United States
Sutter Solano Medical Center/Cancer Center
🇺🇸Vallejo, California, United States
Glendale Memorial Hospital and Health Center
🇺🇸Glendale, California, United States
Valley Medical Oncology Consultants-Castro Valley
🇺🇸Castro Valley, California, United States
Illinois CancerCare-Spring Valley
🇺🇸Spring Valley, Illinois, United States
Mason District Hospital
🇺🇸Havana, Illinois, United States
Hematology Oncology Associates of Illinois-Highland Park
🇺🇸Highland Park, Illinois, United States
University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
Saint Mary's of Michigan
🇺🇸Saginaw, Michigan, United States
Southeast Missouri Hospital
🇺🇸Cape Girardeau, Missouri, United States
Saint Francis Medical Center
🇺🇸Cape Girardeau, Missouri, United States
Miller-Dwan Hospital
🇺🇸Duluth, Minnesota, United States
Virtua Voorhees
🇺🇸Voorhees, New Jersey, United States
North Memorial Medical Health Center
🇺🇸Robbinsdale, Minnesota, United States
Roswell Park Cancer Institute
🇺🇸Buffalo, New York, United States
Inspira Medical Center Vineland
🇺🇸Vineland, New Jersey, United States
State University of New York Downstate Medical Center
🇺🇸Brooklyn, New York, United States
Genesis Healthcare System Cancer Care Center
🇺🇸Zanesville, Ohio, United States
North Shore University Hospital
🇺🇸Manhasset, New York, United States
Lima Memorial Hospital
🇺🇸Lima, Ohio, United States
Cleveland Clinic Akron General
🇺🇸Akron, Ohio, United States
FirstHealth of the Carolinas-Moore Regional Hospital
🇺🇸Pinehurst, North Carolina, United States
Toledo Clinic Cancer Centers-Maumee
🇺🇸Maumee, Ohio, United States
Aultman Health Foundation
🇺🇸Canton, Ohio, United States
Geisinger Medical Group
🇺🇸State College, Pennsylvania, United States
The Center for Cancer and Blood Disorders-Fort Worth
🇺🇸Fort Worth, Texas, United States
Rapid City Regional Hospital
🇺🇸Rapid City, South Dakota, United States
Texas Oncology- San Marcos
🇺🇸San Marcos, Texas, United States
Texas Oncology - Round Rock Cancer Center
🇺🇸Round Rock, Texas, United States
Saint John Macomb-Oakland Hospital
🇺🇸Warren, Michigan, United States
Pennsylvania Hospital
🇺🇸Philadelphia, Pennsylvania, United States
Samaritan North Health Center
🇺🇸Dayton, Ohio, United States
Fox Chase Cancer Center
🇺🇸Philadelphia, Pennsylvania, United States
Saint Joseph Mercy Oakland
🇺🇸Pontiac, Michigan, United States
Missouri Baptist Medical Center
🇺🇸Saint Louis, Missouri, United States
University of Pittsburgh Cancer Institute (UPCI)
🇺🇸Pittsburgh, Pennsylvania, United States
Kalispell Regional Medical Center
🇺🇸Kalispell, Montana, United States
Kalispell Medical Oncology
🇺🇸Kalispell, Montana, United States
Montana Cancer Specialists
🇺🇸Missoula, Montana, United States
Berdeaux, Donald MD (UIA Investigator)
🇺🇸Great Falls, Montana, United States
Saint Vincent Frontier Cancer Center
🇺🇸Billings, Montana, United States
Northern Montana Hospital
🇺🇸Havre, Montana, United States
Montana Cancer Consortium NCORP
🇺🇸Billings, Montana, United States
Benefis Healthcare- Sletten Cancer Institute
🇺🇸Great Falls, Montana, United States
Lancaster General Hospital
🇺🇸Lancaster, Pennsylvania, United States
Truman Medical Center
🇺🇸Kansas City, Missouri, United States
Doctors Carrol, Sheth, Raghavan
🇺🇸Louisville, Kentucky, United States
Saint Luke's Hospital of Kansas City
🇺🇸Kansas City, Missouri, United States
Radiation Oncology Practice Corporation South
🇺🇸Kansas City, Missouri, United States
North Kansas City Hospital
🇺🇸Kansas City, Missouri, United States
Heartland Hematology and Oncology Associates Incorporated
🇺🇸Kansas City, Missouri, United States
Radiation Oncology Practice Corporation - North
🇺🇸Kansas City, Missouri, United States
Louisiana State University Health Science Center
🇺🇸New Orleans, Louisiana, United States
University Medical Center New Orleans
🇺🇸New Orleans, Louisiana, United States
Ochsner Medical Center Jefferson
🇺🇸New Orleans, Louisiana, United States
Texas Oncology-Austin Midtown
🇺🇸Austin, Texas, United States
Texas Oncology - South Austin Cancer Center
🇺🇸Austin, Texas, United States
Texas Oncology - Central Austin Cancer Center
🇺🇸Austin, Texas, United States
Texas Oncology-Austin North
🇺🇸Austin, Texas, United States
Texas Oncology Seton Northwest
🇺🇸Austin, Texas, United States
Virginia Commonwealth University/Massey Cancer Center
🇺🇸Richmond, Virginia, United States
Mercy Medical Center - Des Moines
🇺🇸Des Moines, Iowa, United States
Mercy Capitol
🇺🇸Des Moines, Iowa, United States
Iowa Methodist Medical Center
🇺🇸Des Moines, Iowa, United States
Iowa-Wide Oncology Research Coalition NCORP
🇺🇸Des Moines, Iowa, United States
Medical Oncology and Hematology Associates-Des Moines
🇺🇸Des Moines, Iowa, United States
Medical Oncology and Hematology Associates-Laurel
🇺🇸Des Moines, Iowa, United States
Iowa Lutheran Hospital
🇺🇸Des Moines, Iowa, United States
Montefiore Medical Center-Wakefield Campus
🇺🇸Bronx, New York, United States
Montefiore Medical Center - Moses Campus
🇺🇸Bronx, New York, United States
UW Health Oncology-One South Park
🇺🇸Madison, Wisconsin, United States
Dean Hematology and Oncology Clinic
🇺🇸Madison, Wisconsin, United States
University of Wisconsin Hospital and Clinics
🇺🇸Madison, Wisconsin, United States
Michiana Hematology Oncology PC-Mishawaka
🇺🇸Mishawaka, Indiana, United States
Mercy Hospital Saint Louis
🇺🇸Saint Louis, Missouri, United States