NCT01738828Unknown不适用
Genetic Loci and the Burden of Atherosclerotic Lesions
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 10,000
- 试验地点
- 48
- 主要终点
- Genome-Wide Association
研究概览
简要总结
The GLOBAL study is an international multi-center, prospective study designed to enroll up to 10,000 consecutive eligible subjects who are clinically referred for coronary CT angiography for assessment of suspected coronary artery disease (CAD).
The purpose of the study is to perform extensive biomarker analysis of atherosclerosis in patients phenotyped using advanced imaging modalities of atherosclerosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Caucasian and of Non-Hispanic or Non-Latino origin
- •Referral for coronary CT angiography to evaluate for presence of CAD
- •The patient has signed the appropriate Institutional Review Board approved Informed Consent Form
排除标准
- •Immunosuppressive or immunomodulatory therapy including any dose of systemic corticosteroids in the preceding 30 days (except if steroids are administered as pre-medication prior to contrast administration for CT scan within 24 hours).
- •Chemotherapy in the preceding year
- •Major surgery in the preceding 2 months
- •Blood or blood product transfusion in the preceding 2 months
- •Subjects for whom coronary CT angiography is contraindicated per institutional standard of care
- •Subjects with previous coronary arterial revascularization (PCI or CABG)
- •Subjects with atrial fibrillation/flutter or frequent irregular or rapid heart rhythms, which occurred within the past 3 months
- •Subjects with a pacemaker or implantable cardioverter-defibrillator implant
- •Active congestive heart failure or the presence of known non-ischemic cardiomyopathy
- •Known genetic disorders of atherosclerosis, lipid or lipoprotein metabolism
结局指标
主要结局
Genome-Wide Association
时间窗: Baseline
The primary analysis will be a genome-wide association analysis, to determine candidate genes and markers underlying coronary artery disease.
次要结局
未报告次要终点
研究者
研究点 (48)
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