The Effects of L-arabinose in a Meal on Glucose Metabolism in Healthy Men
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Copenhagen
- Enrollment
- 17
- Primary Endpoint
- Glucose
Study Overview
Brief Summary
The purpose of this study is to investigate the effect of a meal containing different doses of L-arabinose, on the intestinal sucrase activity after intake We measure this by measuring the glucose, insulin and c-peptide after meals. Other measurements are made (glucagon and GLP-1) to explain the correlations.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Prevention
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 30 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy male
- •normal weight (BMI 18,5-25 kg/m2)
- •18-30 years of age
Exclusion Criteria
- •Not healthy,including those with diabetes Mellitus, high bloodpressure, dyslipidemia or a infectious diseases (hepatitis or HIV), gastrointestinal disorders
- •Central adipositas (defined as waist circumference > 94 cm for european men)
- •Daily intake of vitamins and minerals, 3 months before the trail starts and during the trail.
- •elevated alcoholcunsumption(> 21 units af alcohol pr. week)
- •take medicine
- •Elite athlete with intensive training
- •given bloddonation within the last 3 months
Arms & Interventions
10 % arabinose meal starch
A meal containing two bons with butter and cheese, The and water
Intervention: L-arabinose - effect on glucose metabolism (Dietary Supplement)
0% arabinose meal sucrose/starch
A meal containing a bon with butter and marmalade, a cup cake, The and water
Intervention: L-arabinose - effect on glucose metabolism (Dietary Supplement)
5 % arabinose meal sucrose/starch
A meal containing a bon with butter and marmalade, a cup cake, The and water
Intervention: L-arabinose - effect on glucose metabolism (Dietary Supplement)
10 % arabinose meal sucrose/starch
A meal containing a bon with butter and marmalade, a cup cake, The and water
Intervention: L-arabinose - effect on glucose metabolism (Dietary Supplement)
0 % arabinose meal Starch
A meal containing two bons with butter and cheese, The and water
Intervention: L-arabinose - effect on glucose metabolism (Dietary Supplement)
5 % arabinose meal starch
A meal containing two bons with butter and cheese, The and water
Intervention: L-arabinose - effect on glucose metabolism (Dietary Supplement)
Outcomes
Primary Outcomes
Glucose
Time Frame: -15, 0, 15, 30, 45, 60, 90, 120, 180 min
Level of glucose over time, The AUC, the peak value and time to peak
Insulin
Time Frame: -15, 0, 15, 30, 45, 60, 90, 120, 180 min
Level of insulin over time, the AUC, the peak value and time to peak
C-peptide
Time Frame: -15, 0, 15, 30, 45, 60, 90, 120, 180 min
Level of c-peptide over time, The AUC, the peak value and time to peak
Secondary Outcomes
- Glucagon(-15, 0, 15, 30, 45, 60, 90, 120, 180 min)
- GLP-1(-15, 0, 15, 30, 45, 60, 90, 120, 180 min)
Investigators
AAstrup
Dr.Med.Sci./Ph.D.
University of Copenhagen