The effects of prenatal vitamin D supplementation on child health

Not Applicable

Completed

Conditions: Topic: Generic Health Relevance and Cross Cutting Themes
Subtopic: Generic Health Relevance (all Subtopics)
Disease: Paediatrics
Respiratory
Asthma

Registration Number: ISRCTN68645785

Lead Sponsor: Imperial College London (UK)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 180

Inclusion Criteria

All of the offspring of the 180 mothers recruited in the Vitamin D deficiency and supplementation during pregnancy trial are eligible and are invited to participate in this follow up study when their children are 3 years of age.

Exclusion Criteria

Severe congenital or developmental abnormalities likely to significantly affect respiratory health or lung function, e.g., congenital thoracic dystrophy.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Percentage (%) of children with any wheezing episode in the first 3 years of life, measured at 36 - 48 months

Secondary Outcome Measures

Name	Time	Method
All measured at 36 - 48 months:<br>1. % of children using inhaled bronchodilators in the last 12 months<br>2. % of children with doctor diagnosed rhinitis<br>3. % of children with any wheezing episode in the preceding 12 months<br>4. % of children with doctor diagnosed asthma<br>5. % of children with doctor diagnosed eczema<br>6. % of children with doctor diagnosed food allergy<br>7. % of children with positive skin prick test responses<br>8. 25-hydroxyvitamin D levels<br>9. Bronchodilator responsiveness<br>10. Exhaled nitric oxide level (in parts per billion)<br>11. Nasal secretions for inflammatory mediators<br>12. Pulmonary airflow resistance and reactance at a range of frequencies using impulse oscillometry<br>13. Total number of all wheezing episodes since birth<br>14. Total number of upper and lower respiratory tract infections since birth