To explore the mechanism of NF-?B signaling pathway on diabetic peripheral neuropathy by using the method of

Not Applicable

• Conditions: Diabetic peripheral neuropathy

• Registration Number: ITMCTR2100005365
• Lead Sponsor: Affiliated Hospital of Chengdu University of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Age 18-75;
2. Inpatients meeting the diagnostic criteria for diabetes;
3. Meet the diagnostic criteria for DPN in the 2017 Chinese Guidelines for the Prevention and Treatment of Type 2 diabetes;
4. Blood glucose control was stable for more than 2 weeks under hypoglycemic drugs and insulin treatment: FPG=8mmol/L, 2hPG=11mmol/L, and HbA1c= 8%;
5. Self-care, normal thinking, capable of language communication;
6. Those who voluntarily participate in the study and sign the informed consent;
7. Patients who had been in the Department of Endocrinology of The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine for =4 weeks.

Exclusion Criteria

1. Patients with damaged skin integrity at acupoint selection and pestle site, dermatitis, allergy and other skin diseases, or skin allergy to metal;
2. Ketosis and ketoacidosis;
3. Acute infectious diseases;
4. Varicose veins or edema of lower limbs;
5. After lower limb vascular surgery;
6. Complicated with serious primary diseases of heart, liver, kidney and hematopoietic system and mental diseases;
7. Severe visual impairment or blindness;
8. Cancer patients;
9. Pregnant patients.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Tumor necrosis factor -a;Interleukin-1 ß;Clinical Symptom Integral Table;Interleukin-6;