Growth and Development of Premature Babies
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 主要终点
- Growth at 4 months corrected months age
研究概览
简要总结
There are few scientific reports on preterm infants with birth weights between 1500 and 2000g. Adequate and properly balanced supply of nutrients believed to better growth and cognitive development in this patient group, and optimized nutrition is an important part of treatment There is a need for more studies that can provide knowledge of growth and weight development in preterm and small for gestational age (SGA) infants with a birth weight between 1500 and 2000g.
详细描述
There has been little focus, at least there are few scientific reports on preterm infants with birth weights between 1500 and 2000g, at least in Norway. Studies have shown the benefit of enhanced protein and energy supplements in very low birth weight infants (VLBW, birth weight < 1500g), regarding growth and neurodevelopment . Adequate and properly balanced supply of nutrients is believed to give better growth and cognitive development in premature infants with slightly higher birth weight, i.e between 1500 and 2000g (1). In an intervention study of VLBW children at four Norwegian hospitals we found lower supply of energy and protein than international recommendations (2). A larger proportion of premature children were stunted growth (weight below 10 percentile for age) during hospitalization. Although this applies to preterm infants with birth weight less than 1500 g, this may also be the case for larger premature patients.
More studies that can provide knowledge of growth rate, weight and neurodevelopmental outcomes in preterm and small for gestational age (SGA) infants are warranted. This study examines those with birth weight between 1500 and 2000g. Overall, this may provide new and useful knowledge that can help to optimize the nutrition to preterm and SGA infants with a this range of birth weights
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 26 Weeks 至 35 Weeks（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Birth weight between 1500 and 2000g.
- •No invasive catheters or ventilator (wish homogeneous group).
- •No malformations or chromosomal disorders.
- •Parents give informed written consent
- •Born at study hospitals
排除标准
- •Birth weight below 1500 and above 2000g.
- •Invasive catheters or ventilator.
- •Malformations or chromosomal disorders.
结局指标
主要结局
Growth at 4 months corrected months age
时间窗: From birth until 4 months postmenstrual age (PMA)
Growth from birth, during hospital stay, at discharge/term and at 4 months PMA.
Breastfed, full or partly, and solid food at 4 months PMA
时间窗: From birth until 4 months PMA
Eating habits at discharge/term and at 4 months PMA .
次要结局
未报告次要终点
研究者
Elin Wahl Blakstad
dr. Elin Wahl Blakstad
University Hospital, Akershus