Ability of plethysmographic perfusion index to detect fluid responsiveness during the immediate post-operative period in cardiothoracic surgery patients – a prospective observational study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- To study the reliability of change in plethysmographic perfusion index for predicting fluid responsiveness immediately following admission in adult postoperative ICU after cardiothoracic surgery till peripheral temperature is increased
研究概览
简要总结
Hemodynamic management post-cardiac surgery is crucial for optimal patient outcomes. Hemodynamic instability is common, exacerbated by hypovolemia and vasodilation. The goal is to maintain perfusion and oxygen delivery, targeting variables like heart rate, mean arterial pressure, and central venous pressure. Fluid resuscitation is vital for early instability, addressing blood loss, vascular capacitance, fluid losses, and increased preload requirements. Assessing preload dynamics is challenging, with static pressures poorly predicting fluid responsiveness. Dynamic approaches like pulse pressure and stroke volume variation have limitations.
Plethysmographic perfusion index (PI) offers a non-invasive method to assess fluid responsiveness. PI, derived from pulsatile and non-pulsatile light absorption, reflects arterial volume changes during the cardiac cycle. PI varies with changes in vascular tone, making it a potential indicator of fluid responsiveness. Studies show correlations with vascular tone changes induced by anesthesia and vasopressors.
Our study aims to validate PI for detecting fluid responsiveness in postoperative cardiac patients during warming until peripheral temperature reaches 30 C. We’ll also explore the correlation between PI changes and fluid requirements. If proven reliable, PI could revolutionize non-invasive fluid assessment, aiding cardiac care providers in optimal postoperative fluid resuscitation.
Hypothesis:
There is correlation between change in plethysmographic perfusion index and postoperative fluid responsiveness in immediate postoperative period in patients who underwent cardiothoracic surgery.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)(—)
- 性别
- All
入选标准
- •All postoperative adult patients scheduled for elective cardiothoracic surgery.
排除标准
- •Refusal to participate Emergency surgeries Redo surgery Severe LV dysfunction Preoperative inotropic requirement Arrythmias Vasoactive-inotrope score of more than 15 Massive blood loss Patients on renal replacement therapy.
结局指标
主要结局
To study the reliability of change in plethysmographic perfusion index for predicting fluid responsiveness immediately following admission in adult postoperative ICU after cardiothoracic surgery till peripheral temperature is increased
时间窗: 0 min, 15 min, 30 min, 60 min, 120 min
次要结局
- To compare change in plethysmographic perfusion index with parameters involving change in VTI, CVP, IVC diameter for detecting fluid responsiveness.(In fluid responders, whether any change in PPI can predict the fluid requirement)
研究者
Dr Abinaya Prakashbabu U
Sree Chitra Thirunal Institute of Medical Sciences and Technology
