Short Integrative And Neurocognitive Therapy For Young Adults With Borderline Personality Disorder

Not Applicable

Recruiting

• Conditions: Borderline Personality Disorder
• Interventions: Other: SINTYA

• Registration Number: NCT05913544
• Lead Sponsor: Centre Hospitalier Universitaire de Nīmes

Brief Summary

Borderline personality disorder (BPD) is a severe, high-suicidal psychiatric disorder associated with impulsive, endangering behaviors. Young patients between 16 and 25 years old do not respond to traditional psychotherapies, which are often long and not adapted to their neurocognitive alterations linked to early trauma. The study authors hypothesize the SINTYA therapy program (one group session and one individual session weekly for 10 weeks) would reduce the level of impulsivity and clinical symptomatology (severity of the BPD; emotional regulation difficulties; dissociative symptoms; aggressiveness; ruminations; the number of self-destructive behaviors and suicidal acts; impulsive behaviors; level of suicide risk and hopelessness; the number of psychiatric hospitalizations and emergency visits for psychiatric reasons; and finally improving psychosocial functioning).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-05-22
• Study First Submitted QC: 2023-06-12
• Study First Posted: 2023-06-22
• Study Start: 2023-11-08
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-11
• Last Update Posted: 2025-04-14
• Primary Completion: 2026-09
• Study Completion: 2026-09

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 74

Inclusion Criteria

• Diagnosis of BPD according to DSM-5 criteria and BPQ-80 scale.
• High BPD severity level: ZAN-BPD (score ≥ 18/36).
• Understand, write and read French.
• Be able to understand the nature, purpose and methodology of the study and agree to cooperate during evaluations.
• Have signed the informed consent.
• For minor patients, have signed the parental consent by at least one holder of parental authority.

Exclusion Criteria

• Refusal to participate.
• Existence of a neurological pathology or cerebral sequelae of organic origin which could affect neurocognitive performance.
• Intelligence quotient < 70.
• Lifetime diagnosis of schizoaffective disorder or schizophrenia (MINI-7).
• Previous or current participation in specific psychotherapy for BPD.
• Subject deprived of liberty (by judicial or administrative decision) and/or protected by law.
• Inclusion in another study including psychotherapy for the duration of the study.
• Inclusion in a drug RIPH1 study or in a REC study (European regulation of clinical trials) for the entire duration of the study.
• Subject in period of exclusion from another research protocol.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
SINTYA group	SINTYA	-

Primary Outcome Measures

Name	Time	Method
Variation in explicit impulsivity between groups	Month 4	UPPS-S (Impulsive Behavior Scale Short version score)

Secondary Outcome Measures

Name	Time	Method
Variation in explicit impulsivity between groups	Month 7	UPPS-S (Impulsive Behavior Scale Short version score)
Number of self-destructive behaviors between groups	Month 7	Number of self-destructive/self-mutilatory/parasuicidal acts reported by the patient in a clinical interview
Variation in impulsiveness between groups	Month 7	Barratt Impulsiveness Scale (BIS-11) (score out of 120)
Risk taking between groups	Month 7	Balloon Analogue Risk Task (BART)
BPD severity level between groups	Month 7	Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) (score out of 36)
Emotional regulation capacities between groups	Month 7	Difficulties in Emotion Regulation Scale (DERS-18)
Aggression between groups	Month 7	Aggression Questionnaire (AQ-12)
Psychosocial functioning between groups	Month 7	Functional Assessment Staging Tool (FAST)
Decision making under risk conditions between groups	Month 7	Game Dice Task (GDT)
Level of suicide risk between groups	Month 7	Columbia-Suicide Severity Rating Scale (C-SSRS)
Dissociative symptoms between groups	Month 7	Dissociative Experiences Scale (DES): a score of 25 or higher is predictive of dissociative disorder
Ruminations between groups	Month 7	Rumination Reflection Questionnaire (RRQ)
Number of impulsive behaviors between groups	Month 7	Number of impulsive behaviors (food, motor vehicles, sexual, drug-related)
Number of psychiatric hospitalizations and emergency visits for psychiatric reasons between groups	Month 7	Information taken from patient medical file
Implicit impulsivity between groups	Month 7	Continuous Performance Test (CPT)
Neurocognitive evaluation of implicit impulsivity between groups	Month 7	Emotional Stroop (SE) customized to the study

Trial Locations

Locations (1)

CHU de Nîmes; 🇫🇷 Nîmes, France